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題名 | Use of Older Red Blood Cells in Low Birth Weight Infants=較老紅血球濃厚液在低體重兒之使用 |
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作者 | 陳中明; Chen, Chung-ming; |
期刊 | 慈濟醫學 |
出版日期 | 19960300 |
卷期 | 8:1 1996.03[民85.03] |
頁次 | 頁13-19 |
分類號 | 417.5 |
語文 | eng |
關鍵詞 | 輸血; 低體重兒; 捐血者暴露; Blood transfusion; Low birth weight infant; Donor exposure; |
中文摘要 | 非常低體重兒經常需要輸注多次的紅血球,因此會暴露於很多位捐血 者,增加了發生輸血副作用的可能性,特別是與輸血相關的感染性疾病。我們假 設輸注較老紅血球濃厚液不會改變血液的酸鹼值和電解質,並且可以降低捐血者 暴露率。本研究樣本包括未曾輸過血以及其他可能需要多次輸血的低體重兒。血 液保存在附有一空衛星袋的輸血袋內,故一單位紅血球濃厚液在35天內可以分兩 次使用。我們在輸血前及輸血後的1~2小時測量嬰兒的動脈氣體分析、血色素、 血漿鈉、鉀及鈣濃度。總共有七位嬰兒(平均上標準誤,出生體重1186±103公克, 懷孕週數29.6±0.7週,年齡19.4±4.2天)接受18次紅血球濃厚液(眾數(範圍)8天 (1~27天))輸血。結果:平均血紅素和鈣濃度在輸血後呈有意義地增加,而酸鹼值、 鈉及鉀濃度則沒有差別。輸血後無副作用發生,而且生命徵象也沒有改變。結論: 早產兒使用較老紅血球濃厚液是安全的,而且可以降低暴露很多捐血者的機率。 (慈濟醫學1996;8:13-19) |
英文摘要 | Very low birth weight infants, particularly those of less than 30 weeks' gestation, usually requiremultiple red blood cell transfusions. Exposure to blood from multiple donors increases the potential for adverse effects, particularly transfusion-associated infections. In this study we hypothesized that usingolder packed red blood cell (PRBC) transfusions would not significantly alter acid base and serumelectrolytes, but would decrease exposure to blood from multiple donors. The blood was preserved incitrate phosphate dextrose adenine (CPDA) solution and provided as a main unit with one emptysatellite bag so that two separate transfusions can be given before the expiry date 35 day later. The infants' arterial blood gas, hemoglobin, plasma sodium, potassium, and calcium were measured justbefore and 1-2 hours after each transfusion. Seven infants (mean±SE, birth weight 1186±103 gm, gestational age 29.6±0.7 weeks) received 18 transfusions of 15 ml/kg of PRBC over 3 hours. The median(range) age of the PRBC transfused was 8 days (1-27 days). Following transfusion, there was asignificant increase in hemoglobin (10.5±0.3 to 13.3±0.2 gm/dL) and calcium concentrations(2.20±0.08 to 2.34±0.06 mmol/L). Acid base, plasma sodium, and potassium concentrations were notsignificantly different. Vital signs remained stable during the transfusions. We conclude that CPDApreserved older PRBC may be safe for use in premature infants and they can be used to decrease donorexposure risk for infants requiring multiple blood transfusions.(TZU Chi Med J 1996,8: 13-19 ) |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。