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題名 | Serum Leptin Levels in Preterm, Healthy and Sick-Term Newborns=早產兒、足月健康兒及足月病兒血中瘦體蛋白之分析 |
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作者 | 蘇本華; 王淑麗; 陳家玉; 張賴昇平; 簡淑華; Su, Pen-hua; Wang, Shu-li; Chen, Jia-yuh; Chang Lai, Cheng-pin; Jian, Shu-hua; |
期刊 | 臺灣兒科醫學會雜誌 |
出版日期 | 20020900、20021000 |
卷期 | 43:5 民91.09-10 |
頁次 | 頁249-254+299 |
分類號 | 417.5 |
語文 | eng |
關鍵詞 | 瘦體蛋白; 肥胖基因; 早產兒; 足月兒; 體重; Leptin; Obese gene; Preterm; Term; Body weight; |
中文摘要 | 瘦體蛋白主要由身體脂肪細胞制造,以荷爾蒙的型態提供腦部有關身體能量儲存量之多寡的訊息,並活化下視丘中樞以達到調節能量攝取及消耗能量的作用。胎兒時期的生長速率非常快,特別是在妊娠後期胎兒的體重急速增加,身體脂肪及蛋白質比例亦顯著上升。這樣的變化是否會經由與能量調節極有關連的瘦體蛋白來呈現特別的變化呢?因此我們希望能經由本研究,分析台灣早産兒與足月兒血清中瘦體蛋白的濃度,並經由統計學的方法,了解新生兒的出生體重、身長、頭圍、腰圍、臀圍、週數、體表面積、身體質量指數及性別,分別與血清中瘦體蛋白濃度的相關性。本篇研究論文中對於104位新生兒,分別依其出生週數及臨床表現分爲早産兒、足月健康兒及足月滿兒三組。根據統計分析指出(1)血清中瘦體蛋白濃度與出生體重、身長、體表面積,有顯著相關。(2)足月健康兒血清中瘦體蛋白濃度明顯高於足月病兒與早産兒。(3)不同性別的三組新生兒血清中瘦體蛋白濃度有女高於男的趨勢,但經由統計分析後有顯著差異。(4)新生兒血清中瘦體蛋白濃度隨出生時妊娠週數及體重的增加而上升,且有線性關系。 |
英文摘要 | Leptin, a hormone that signals the brain about the status of body (fat) energy stores, has recently been shown to play a role in the regulation of several hypothalamic pituitary axes, including the growth hormone axis. To investigate a potential association of serum leptin concentrations and clinical condition in preterm, sick term and healthy term newborns, serum leptin concentrations were evaluated in 104 newborns. Twenty-eight of them were healthy term (18 males and 10 females; gestational age, 37-42 weeks), 21 were sick term (12 males and 9 females; gestational age, 37-42 weeks) and 55 were preterm neonates (35 males and 20 females; gestational age: 26-37 weeks). Leptin values correlate positively with birth weight, birth length, head circumference, waist circumference, hip circumference, body surface, weight/length ratio, and gestational age (r=0.38, 0.42, 0.29, 0.21, 0.29, 0.40, 0.31 and 0.28), respectively. The concentrations of leptin are statistically significantly higher (p<0.05) in term neonates (3.02±2.94ng/ml) than preterm neonates (1.93±2.21ng/ml). Female infants also have significantly higher (p<0.05) serum leptin values than male infants in preterm and healthy term groups. We also found leptin present in venous blood after 26 weeks of gestation. |
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