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來源資料
頁籤選單縮合
題名 | Results of the Treatment off Squamous Carcinoma of the Anal Canal=肛門鱗狀上皮癌治療結果 |
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作者 | 楊純豪; 林楨國; 林資琛; 陳維熊; 陳培勳; 季匡華; 顏上惠; 陳光耀; 徐弘; Yang, Shung-haur; Lin, Jen-kou; Lin, Tzu-chen; Chen, Wei-shone; Chen, Pai-hsuen; Chi, Kuan-hwa; Yen, Sang-hue; Chen, Kuang Y.; Hsu, Hung; |
期刊 | 中華民國外科醫學會雜誌 |
出版日期 | 19960500、19960600 |
卷期 | 29:3 民85.05-06 |
頁次 | 頁220-228 |
分類號 | 416.245 |
語文 | eng |
關鍵詞 | 肛門鱗狀上皮癌; Anal canal; Squamous; Cloacogenic; Carcinoma; Chemoradiation therapy; Radiation therapy; Abdominoperineal resection; |
中文摘要 | 從1962年二月至1995年四月止,有81位肛門鱗狀上皮癌的病人在台北榮 總接受治療,其中4I位接受腹部會陰切除術(APR),22位接受化學及放射合併療 法(CRT),10位只接受放射治療(RT)。 結果四年粗存活率(crudesurvivalrate)在不同的治療組別為:腹部會陰切除術59,化 學及放射合併療法59,放射治療15(P=0.09),三年及五年病因特定存活率 (cause-specificsur-vivalrate)為腹部會陰切除術69、60;化學及放射合併療法65、53; 放射治療為57(三年)。 以同樣StageIllb的病人來講,五年存活率為腹部會陰切除術27。化學及放射合併 療法37。 我們的研究顯示存活率是與局部腫瘤程度,及腫瘤細胞分化程度有意義相關的 (P=0.05)。腹部會陰切除術的局部腫瘤復發率(local recurrencerate)及骨盆腔外腫瘤 復發率(extrapelvic recurrence rate)分別是20、20。而化學及放射合併療法的局部腫 瘤復發率及骨盆腔外腫瘤復發率是31.6、26.3。我們相信化學及放射合併療法的 高復發率是因為其中有較多的晚期病人所致。 化學及放射合併療法治療中,在治療完成時的完全復原比率(complete remission rate)是86.3(19/22),人工造口率是(colostomy rate)32(7/22),而主要的決定因素是局 部腫瘤是否獲得控制。 |
英文摘要 | From February 1962 to April 1995, eighty-one patients with epidermoid carcinoma of the anal canal were treated at Taipei Veterans General Hospital(Taipei VGH). Forty-nine of these patients were treated by abdominoperineal resection (APR), 22 patients by combined chemoradiationtherapy (CRT), while 10 patients received radiation therapy only (RT). Thecrude four-year survival rate for the different treatment groups was: APR,59; CRT, 59; RT 15 (p=0.029). Cause-specific survival rate at three andfive years were: 69, 60 in APR; 65, 53 in CRT; 57 (Syr) in RT group(p=0.54). In stage Illb patients, the five-year cause-specific survival was27 in APR and 37 in CRT. The study revealed that the survival rate issignificantly influenced by local tumor (T) status and the degree of tumorcell differentiation (p=0.05). The local recurrence rate and extrapelvicrecurrence rate were 20, 20 in APR; 31.6, 26.3 in CRT. It seemed thatthe higher recurrent rate in CRT was because those were more advancedcases. In CRT group, the complete remission rate at the end of treatmentwas 86.3 (19/22). The eventual colostomy rate was 32 (7/22); the majorfactor causing colostomy is local tumor control. These results suggest thatCRT is at least as effective as APR and can also avoid the necessity of colostomy for most patients. |
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