頁籤選單縮合
題名 | Endogenous Endothelium-Derived Relaxing Factor Inhibits Platelet Adhesion under Whole Blood Flow Conditions ex Vivo= |
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作者 | 任卓穎; 陳佳黛; 陳洵瑛; |
期刊 | 中國生理學雜誌 |
出版日期 | 19950900 |
卷期 | 38:3 1995.09[民84.09] |
頁次 | 頁147-151 |
分類號 | 414.7 |
語文 | eng |
關鍵詞 | EDRF; Platelet adhesion; Flow condition; |
英文摘要 | In this study, we used carbachol to stimulate the endogenous endothelium-derived relaxing factor (EDRF) release in male Sprague-Dawley rats. One ml of native blood was drawn from the femoral artery and directly passed through a parallel-plate flow chamber. This system allowed us to examine ex vivo platelet adhesion to fibrinogen-coated surface under whole blood flow conditions. Our results demonstrated that 1) the intravenous administration of carbachol induced a transient decrease of blood pressure, reduction in platelet adhesion ex vivo, and elevation in platelet cGMP level; 2) coadministration of carbachol with hemoglobin, a scavenger of EDRF, inhibited these carbachol effects; 3) the administration of hemoglobin or N(superscript ω)-nitro-L-arginine, an inhibitor blocking the NO synthesis pathway, caused elevated blood pressure in vivo, increased platelet adhesion ex vivo, and decreased cGMP content in platelets. We conclude that endogenous EDRF not only modulates vascular tone, but also influences platelet adhesion under flow conditions. |
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