頁籤選單縮合
題名 | Schedule-Induced Polydipsia Increased Both Mesotelencephalic-Dopaminergic and Pontine-Noradrenergic and Pontine-Noradrenergic Activities in the Rat Brain= |
---|---|
作者 | 童吉士; 呂志成; 劉亞平; 曾清俊; 尹在信; |
期刊 | 中國生理學雜誌 |
出版日期 | 19950600 |
卷期 | 38:2 1995.06[民84.06] |
頁次 | 頁57-63 |
分類號 | 415.121 |
語文 | eng |
關鍵詞 | Schedule-induced polydipsia; Central monoaminergic systems; Transmissions; |
英文摘要 | We have demonstrated previously that the activity of schedule-induced polydipsia (SIP) was persistently depressed after successive lesions of the bilateral symmetrical locus coeruleus and the ventral tegmental area. The hypothesis that central catecholaminergic neurons mediate animal behaviors in arousal or coping processes, e.g., SIP, was tested by the demonstration of concomitant changes of transmissions in regions of appropriate nerve terminals. By using the high performance liquid chromatography coupled with electrochemical detection methods, the current experiments were designed to examine the regional turnover of monoamines in the performance of STP of the control rats by measurements of the biochemical derivatives including dopamine (DA), norepinephrine (NE), serotonin (5-HT), 3,4-dihydroxyphenylacetic acid (DOPAC), dihydroxyphenylalanine (DOPA) , 4,-hydroxy-3-methoxyphenylglycol-4-sulfate (MHPG-SO4) and 5-hydroxyindoleacetic acid (5-HIAA). It was found that rats in the performance of SIP, the DA levels and DA synthesis and utilization in the limbic area were incrased and that the NE level and NE synthesis in the several pontine NE projected areas, e.g., limbic area, hippocampus, cortex and pons were also increased. Conversely, both NE and 5-HT metabolism in the hippocampus and the cortex were decreased. We concluded that the enhanced actions of the DA-limbic system and NE-pontine system in the rats are both important for the maintenance of SOP performance. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。