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題名 | Genotoxic and Cytotoxic Effects of Cyclophosphamide and Three Herbicides in Rana Catesbeiana:Cyclophosphamile及三種殺草劑對牛蛙遺傳毒性與細胞毒性的影響= |
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作者 | 陳嘉芬; 蔡淑宜; |
期刊 | 華岡理科學報 |
出版日期 | 19940600 |
卷期 | 11 1994.06[民83.06] |
頁次 | 頁1-15 |
分類號 | 433.85 |
語文 | eng |
關鍵詞 | 牛蛙; 毒性; 殺草劑; 細胞毒性; 遺傳; |
中文摘要 | 利用本實驗室發展出的不連續5-Bromodeoxyuridine處理方法,以研究 cyclophosphamide,殺丹 (saturn),丁基拉草 (butachlor)及甲氧基護古(chlomeoxynil) 對牛蛙(Rana atesbeiana)的遺傳毒性及細胞毒性的影響。Cyclophosphamide為一種已 知的抗癌且是致癌劑,saturn,butachlor及chlomeoxynil為臺灣水田最常用的三種殺 草劑。Cyclophosphamide在低劑量下,所誘導的姊妹染色分體交換頻率(sister chromatid exchange frequencies,SCE)是與劑量的增加成正比,Saturn及butachlor只在 危害動物生命的高劑量下,才會誘導SCE的產生。根據細胞複製指數 (replicative indices)的分析試驗,cyclophosphamide及butachlor只會稍微延緩細胞週期的時間。 然而satlirn卻會顯著降低牛蛙骨髓細胞的複製指數。在所測驗的劑量下, chlomeoxynil不會造成SCE顯著增加,但會延緩細胞分裂週期。比較幾個藥品的最 低有效劑量,cyclophosphamide所誘導的SCE為saturn的22倍,為butachlor的157倍。 本研究結果顯示由本實驗室所發展出來的牛蛙體內SCEs分析方法,可用來偵測環 境中化學物質的遺傳毒性,並有助農藥毒性的評估。 |
英文摘要 | A discontinuous 5 - Bromodeoxyuridine administration method developed byour lab, was utilized to detect the genotoxic and cytotoxic effects ofcyclophosphamide, saturn, butachlor, and chlomethoxynil in Rana catesbeiana.Cyclophosphamide, a well known antitumor agent and a carcinogen, yields a dose dependent increase in the SCEs frequency. Saturn and butachlor induced SCEsin bullfrogs only at a dose which affected the viability of these animals. Analysisof the replicative indices showed that cyclophosphamide and butachlor caused aslight cell - cycle delay whereas saturn caused a dose dependent and significantdecrease in replicative index. Chlomethoxynil did not show any significantincrease in SCEs over baseline at the dosage tested. However a delay in cell cyclewas observed by chlomethoxynil. The present study demonstrates that in vivo SCE method in bullfrogs can be used as a monitoring system for the assessment of environmental genotoxic chemicals. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。