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題 名 | Increased erythrocyte adenosine deaminase activity in asthmatic children=氣喘兒童紅血球Adenosine deaminase活性之上昇 |
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作 者 | 黃焜璋; 王志堯; 謝貴雄; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷 期 | 31:2 民79.03-04 |
頁 次 | 頁76-80 |
分類號 | 417.5343 |
關鍵詞 | 氣喘兒童; 紅血球; Adenosine deaminase活性; |
語 文 | 英文(English) |
中文摘要 | Adenosine係新被注意到之人類肥大細胞中的一種間質,目前已知氣喘病人吸入adenosine會造成氣管收縮,而Adenosine deaminase (ADA) 係使purine分解成inosine的酵素,自從紅血球ADA缺乏在先天性免疫不全症病患被發現以後,紅血球ADA之異常在很多免疫不全症或感染症中被提出,但迄今在過敏性病患ADA之變化尚未被提起。因此我們對19位剛被診斷為氣喘的新病人,20位受減敏治療之氣喘病人(這兩組病人均對瞞抗原皮膚試驗呈陽性反應)及11位正常兒童,進行紅血球 ADA 之活性檢驗。我們的結果顯示:新病人組之紅血球ADA活性為72.9±30.4μmole/min/unitOD 541nm,減敏組為52.7±37.9umole/min/unitOD 541nm,正常組為39.5±26.7μmole/min/unitOD 541nm。新病人組與正常組之ADA值比較有顯著差異(p<0.05),而新病人組與減敏組、減敏組與正常組之ADA值則差異不明顯(p>0.05,p>0.2)。我們推測在未經治療之氣喘病人,紅血球ADA活性上昇現象可能係因病人之遺傳因素,或過敏病人本身的一種保護作用。 |
英文摘要 | Erythrocyte adenosine deaminase (ADA) activity was measured in 19 newly-diagnosed and 20 hyposensitized asthmatic children, as well as 11 age-matched normal children. ADA activity was determined by adenosine catalyzed reactions. The results showed:1) The mean value of ADA activity was 72.9±30.4μmole/min/unit OD54lnm in newly- diagnosed asthmatics; 52.7±37.9μmole/min/unit OD541nm in hyposensitized patients and 39.5±26.7μmole/min/unit OD54lnm in normal controls; 2) there was significant elevation in erythrocyte ADA activity in newly-diagnosed asthmatic patients as compared to normal controls (P<0.05), but there was no difference between newly-diagnosed and hyposensitized patients (P>0.05), and between hyposensitized patients and normal controls (P>0.2). The mechanism and possible clinical implication of increasing erythrocyte ADA activity in newly-diagnosed asthmatic patients are discussed. |
本系統中英文摘要資訊取自各篇刊載內容。