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題名 | Metabolism of Formosanin-C by Cytochrome P-450=Cytochrome P-450對Formosanin C之代謝作用 |
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作者 | 黃正一; 周光儀; 江雪卿; |
期刊 | 醫學研究 |
出版日期 | 19890700 |
卷期 | 10:1 1989.07[民78.07] |
頁次 | 頁25-32 |
分類號 | 418.2216 |
語文 | eng |
關鍵詞 | 代謝; 作用; |
中文摘要 | 七葉蓮的主要成份PF-3為類脂醇配糖體具實驗性抗肝癌活性,亦具卵巢腫瘤及大腸癌抑制效果。從PF-3離體實驗發現肝臟微粒體胞色素P-450酵素的oxygen binding site可結合FP-3產生Type II的Difference spectrum,□值是78μM,A max值是0.21。由一氧化碳的抑制所誘導的cytochrome P-450的isoenzyme參予且活化PF-3的代謝作用。 |
英文摘要 | Formosanin c is a steroida glycoside isolated from Paris formosana Hayata. It has been known from the previous studies, the growth of solid MH134 mice hepatoma was retarded by 1-2.5 mg/kg Formosanin c, and also isgniicant regression in tumor SK-OV-3 (ovary) and HT-29 (colon) was induced by PF-3. The biotransformation of formosanin c by hepatic cytochrome P-450 has been investigated. The hepatic microsomal cytochrome P-450 enzyme system is capable of binding and metabolizing formosanin c which is shown to bind the type II site (oxygen binding site) of the enzyme at the concentrations of 150μm. The apparent binding constants (Ks) was 78μM. The observed effect of induction of Phenobarbital on A max and Vmax suggests that several of the multiple forms of cytochrome P-450 bind formosanin c. The incubation of Formosanin c with hepatic microsomes of rats in the presense of an NADPH-generating system led to decrease of cytochrome P-450 measured by its carbon monoxide difference spectra, and the decrease was enhanced by Phenobarbital treatment. |
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