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題名 | Inhibitory Effects of Noxious Stimuli on Activities of Neurons in Ventral Tegmental Area=侵害刺激之抑制覆蓋區神經元的活動 |
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作者 | 蔡長添; |
期刊 | 中華農學會報 |
出版日期 | 19870300 |
卷期 | 137 1987.03[民76.03] |
頁次 | 頁80-94 |
分類號 | 364.6791 |
語文 | eng |
關鍵詞 | 抑制; 神經元; 覆蓋區; |
中文摘要 | 以Urethane麻醉鼠作覆蓋區(VTA)神經元的細胞外記錄,藉此電位探討侵害刺激:如夾尾(TP)或熱水燙尾(HW)等對DTA神經元活動的影響及鎮痛對此影響的作用。結果顯示在VTA有A及B二羣神經元。A羣共四十六個神經元,其自發性動作電位有較長的持續時間(Duration)(3~5 msec),放電頻率低(1~6 spikes/sec)及較慢的傳導速度(0.56 m/sec)等特性與黑質多巴胺(Dopamine)神經元的特性類似,因之認為是VTA的多巴胺神經元。B羣共有七個神經元,具較短持續的時間(1~2 msec),放電頻率較高(10~50 spikes/sec)及較快的傳導速度,因與黑質多巴胺神經元的特性完全不同,故認為是非多巴胺神經元。這兩羣神經元都會因Nucleus accumbens的刺激而誘發逆行性動作電位,故由VTA多巴胺及非多巴胺雙重神經纖維分佈到Nucleus accumbens。 A羣的神經元中有91.5%的多巴胺神經元的活動都受到TP及HW的抑制;其抑制程度高達76.87 ± 4.8%及78.75 ± 4.27%。這些抑制皆因Aspirin (500 mg/kg.s.c)及Fentanyl (2.5 mg/kg.iv)的注射而消失。甚至Fentanyl的消除抑制作用,會因Naloxone (0.2 mg/kg.i.v)的注射而使Fentanyl的作用消失,抑制重現。其結果表示(1)由覆蓋區到Nucleus accumbens有雙重神經纖維分佈,(2)VTA中的多巴胺細胞會受到TP或HW疼痛刺激的抑制,(3)Fentanyl的作用是經由鴉片接受體而促成的。 |
英文摘要 | Effects of noxious stimuli, tail pinching (TP) and tail heating with hot water (HW), on the activities of dopamine neurons in the ventral tegmental area (VTA) were studied by the extracellular recording in urethane anesthetized rats. It was found that the area appeared to contain two types of neurons with different electrophysiological properties of spikes. Type A had properties similar to those of nigral dopaminergic neurons: slow firing rates, long spike durations and slow conduction velocities. It was concluded that neurons of this group were probably A10 dopaminergic neurons. Type B had faster firing rates, short spike durations and faster conduction velocities, so they were considered as non-dopaminergic neurons. Fifty-three units which included type A (N=46) and type B (N=7) cells in the ventral tegmental area were antidromically activated by the stimulation of nucleus accumbens. The result suggested that the nucleus accumbens received dual projections of dopaminergic and non-dopaminergic fibers from the ventral tegmental area. The discharge rates of 46 type A cells were tested by TP and HW. The inhibition of neuronal activities was the major response to TP and HW in 42 type A cells (91.5%). The firing rates were reduced 76.87 ± 4.81% by TP and those were reduced 78.75 ± 4.27% by HW. Furthermore, this inhibition was diminished by the injection of sodium aspirin (500 mg/kg, s.c.) and fentanyl (2.5 µg/kg, i.v.); and the action of fentanyl was antagonized by the infection of naloxone (0.2 mg/kg, i.v.). These results apparently indicated that the noxious stimuli evoked inhibition, which similar to those occurred in SNC neurons, of the activities of the VTA neurons; and the modality of the noxious stimuli is likely painful in nature. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。