頁籤選單縮合
題名 | Autonomic Modulation and the Risk of Dementia in a Middle-aged Cohort: A 17-year Follow-up Study |
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作者 | Chou, Yu-tsung; Sun, Zih-jie; Shao, Shih-chieh; Yang, Yi-ching; Lu, Feng-hwa; Chang, Chih-jen; Liao, Tzu-chi; Li, Chung-yi; Chen, Tony Hsiu-hsi; Wu, Jin-shang; Lai, Edward Chia-cheng; | 書刊名 | Biomedical Journal |
卷期 | 46:6 2023.12[民112.12] |
頁次 | 頁(100576)1-(100576)11 |
分類號 | 415.934 |
關鍵詞 | Heart rate variability; Autonomic modulation; Parasympathetic activity; Sympathetic-vagal imbalance; Dementia; |
語文 | 英文(English) |
DOI | 10.1016/j.bj.2022.12.004 |
英文摘要 | Background: Altered autonomic modulation, measured by heart rate variability (HRV), has been found to be associated with dementia risk in the elderly. However, long-term follow- up study evaluating the association between autonomic modulation from middle-age and the incidence of dementia has been limited. Methods: This retrospective cohort analyzed data from Taiwan's National Health Insurance Database covering the period from 2001 to 2017, with a linkage to citywide health exami- nations conducted by Tainan Metropolitan City, Taiwan. We included subjects aged 45e64 years. The mean follow-up period was 15.75 ± 3.40 years. The measurements of HRV included resting heart rate, high frequency (HF), low frequency (LF), standard deviation of normal-to-normal ReR intervals (SDNN), ratio between the 30th and 15th ReR interval after standing up from the supine position (30/15 ratio), ratio between the ReR intervals during expiration and inspiration, and the ratio between the high- and low-frequency compo- nents (LF/HF). The main study outcome was the incidence of dementia. We performed multivariable Cox proportional hazard regression models to compare the risk of dementia among different HRV subgroups. Results: We included 565 participants with a mean age of 53 (SD: 6) years, of whom 44% were male. The risk of dementia was significantly increased in association with lower parasympathetic HRV modulation, including SDNN (HR: 3.23, 95% CI: 1.55e6.73) and 30/15 ratio (HR: 3.52, 95%CI: 1.67e7.42). Moreover, the risk of dementia was increased in subjects with higher LF/HF ratios (HR: 2.05, 95% CI: 1.12e3.72). Conclusions: Lower parasympathetic activity and higher sympathetic-vagal imbalance in middle-age were associated with dementia risk. |
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