頁籤選單縮合
題名 | The Clinical Impact of the Novel Tumor Marker DR-70 in Unresectable Gastric Cancer Patients = |
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作者 | Hung, Yi-ping; Chen, Ming-huang; Lin, June-seng; Hsiao, Chin-fu; Shan, Yan-shen; Chen, Yeu-chin; Chen, Li-tzong; Liu, Tsang-wu; Li, Chung-pin; Chao, Yee; |
期刊 | Journal of the Chinese Medical Association |
出版日期 | 20180700 |
卷期 | 81:7 2018.07[民107.07] |
頁次 | 頁593-598 |
分類號 | 415.527 |
語文 | eng |
關鍵詞 | Chemotherapy; Gastric cancer; Prognosis; Tumor markers; |
英文摘要 | Background: Gastric cancer tumor markers, such as carcinoembryonic antigen (CEA) and cancer antigen 19-9 (CA 19-9), have been applied in clinical practice to screen or monitor treatment responses. However, their sensitivity and specificity are unsatisfactory. Therefore, we assessed the novel tumor marker DR-70 and evaluated its performance in screening and response monitoring. Methods: The study included newly diagnosed patients with advanced gastric cancer from March 2012 to October 2015. We measured the DR-70, CEA, and CA 19-9 levels at the time of enrollment. The patients subsequently underwent chemotherapy. We followed-up the patients every 3 months; DR-70 levels and abdominal computed tomography scans were re-evaluated and repeated, respectively, at each follow-up. The correlation between treatment response and DR-70 level after chemotherapy was analyzed. The overall survival and progression-free survival rates were also evaluated. Results: A total of 51 patients with gastric cancer were enrolled. Most (82.4%) had metastatic disease. At enrollment, the sensitivity of DR-70 in our study group was 78.4%, compared with 52.9% and 43.1% for CEA and CA 19-9, respectively. When we used the three tumor markers together, the sensitivity increased to 80.4%. We observed a correlation between treatment response and DR-70 level after chemotherapy. No difference in either overall survival or progression-free survival was observed between the DR-70 positive and negative groups. However, a trend toward poorer overall survival was observed for the high DR-70 group, although this was not statistically significant. Conclusion: DR-70 is a powerful tool not only for screening unresectable gastric cancer but also for treatment response evaluation. |
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