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題名 | The Prognosis Outcome of Oral Squamous Cell Carcinoma Using HIF-2α= |
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作者 | Lim, Elva; Kuo, Chia-chun; Tu, Hsi-feng; Yang, Cheng-chieh; |
期刊 | Journal of the Chinese Medical Association |
出版日期 | 20171000 |
卷期 | 80:10 2017.10[民106.10] |
頁次 | 頁651–656 |
分類號 | 418.31 |
語文 | eng |
關鍵詞 | HIF-2α; IHC; OSCC; Predictor; |
英文摘要 | Background: Hypoxia-induced factors (HIF) has a role in angiogenesis and regulate tumorigenesis of cancer cell. The HIF is the best-identified mechanism that shows imbalance between consumption and oxygen supply in progressing tumor. This study of HIF-2a expression in oral squamous cell carcinoma (OSCC) aimed to investigate the relationship of HIF-2a and pathology characteristics related to its clinical correlation. Methods: Fifty-eight samples of OSCC and adjacent tissues were fixed in paraffin for microarray preparation. The tissue array then was stained using primary antibody HIF-2a (NB100-122) and autoprobe II ABC universal staining kit. Each tissue sample was captured using camera microscope, and images were analyzed with Photoshop 6.0 using the CMYK method. A statistical analysis was performed with the two-tailed ttest, KaplaneMeier and log-rank test using Prism for Windows version 5.0. Results: The samples of the non-cancerous matched tissues (NCMTs) paired with their OSCC samples showed HIF-2a overexpression with significance difference p < 0.0001. Although no significant difference was found between HIF-2a expression and overall survival rate, cancerspecific survival rate, and disease-free survival rate, the HIF-2a expression showed statistical significance for overall cancer stages with p ¼ 0.013. In addition, patients with high HIF-2a expression tended to develop recurrence within 2 years compared to the low expression group. Conclusion: HIF-2 expression has complicated roles in different cancer types, including OSCC. Our study indicated that HIF-2a overexpression can serve as a good biomarker for cancer status for all tumor stages and may predict an early recurrence within two years. |
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