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題名 | Ceftriaxone引起DRESS之案例=A Case Report of Ceftriaxone Induced Drug Related Rash with Eosinophilia and Systemic Symptoms |
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作者 | 林聖茹; 曹百印; 李宜勳; 謝政智; Lin, Sheng-ru; Tsao, Bai-yin; Li, I-hsun; Hsieh, Cheng-chih; |
期刊 | 藥學雜誌 |
出版日期 | 20151200 |
卷期 | 31:4=125 2015.12[民104.12] |
頁次 | 頁49-54 |
分類號 | 418.281 |
語文 | chi |
關鍵詞 | 藥物過敏反應症候群; 過敏性疾病; 藥物不良反應; Ceftriaxone; Drug-related rash with eosinophilia and systemic symptoms; DRESS; |
中文摘要 | Ceftriaxone 所引起之藥物過敏反應 (Drug-related rash with eosinophilia and systemic symptoms, DRESS) 症候群是一種罕見且可能危及生命之藥物過敏性反應。疾病特性 潛伏期長約2-6週,儘管停用可疑藥品後因為發作期長故有復發的可能性,其復發頻 率與一種潛在性人類皰疹病毒之再活化有關。在一篇前瞻性研究中顯示其年發病率為 0.9/100,0001。初始症狀為皮膚發疹並可能擴展至全身,亦可能同時伴隨發燒、淋巴 結腫大及肝、腎、肺臟等器官發炎,以及血液異常 (包括嗜伊紅性白血球增加、非典 型淋巴球增生) 等症狀。 本案例為一位25歲男性因心內膜炎而使用 ceftriaxone,於治療後發現病人產生藥物 不良反應 (DRESS),本文主要探討個案發生 DRESS 後的臨床症狀與後續處置狀況。 |
英文摘要 | Drug-induced Drug-related rash with eosinophilia and systemic symptoms (DRESS)is a rare, potentially life-threatening, drug-induced hypersensitivity reaction. DRESS is characterized by a long latency (two to six weeks) between drug exposure and disease onset, a prolonged course with frequent relapses despite the discontinuation of the culprit drug, and frequent association with the reactivation of a latent human herpesvirus infection. In a prospective study shows that annual incidence of 0.9/100,0001. Drug-induced hypersensitivity reaction that includes skin eruption, fever, lymphadenopathy ,internal organ involvement (liver, kidney, lung) inflammation and hematologic abnormalities (eosinophilia, atypical lymphocytosis). This article will discuss a 25 year-old male patient with endocarditis after taking ceftriaxone cause severe adverse drug reactions (DRESS). Also, it will include patient clinical feature, medical treatment. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。