頁籤選單縮合
題名 | Influence of Age on Critically Ill Patients with Cirrhosis= |
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作者 | Chen, Cheng-yi; Wu, Chih-jen; Pan, Chi-feng; Chen, Han-hsiang; Chen, Yu-wei; |
期刊 | International Journal of Gerontology |
出版日期 | 20151200 |
卷期 | 9:4 2015.12[民104.12] |
頁次 | 頁233-238 |
分類號 | 417.7452 |
語文 | eng |
關鍵詞 | Critical care; Geriatric; Intensive care unit; Liver cirrhosis; Old age; |
英文摘要 | Background: The general prognosis of critically ill patients with cirrhosis is poor. We investigated the influence of age (< 65 years, 65e74 years, and _ 75 years) on the short- and medium-term outcomes of cirrhotic patients in the intensive-care-unit (ICU) setting. Methods: This retrospective cohort study included 226 consecutive patients with liver cirrhosis who were admitted to the ICU. Clinical outcomes, including ICU mortality, in-hospital mortality, ventilatorfree days, ICU days, ICU-free days, hospital days, and hospital-free days, were compared between the different age groups. Results: The overall ICU mortality in patients aged < 65 years, 65e74 years, and _ 75 years was 29.4%, 20.0%, and 30.3%, respectively. For patients with compensated cirrhosis, age showed no significant correlation with mortality or clinical outcomes. For patients with decompensated cirrhosis, age _ 75 years was significantly correlated with in-hospital mortality, 6-month mortality, hospital days, and hospitalfree days. After adjusting for sex, coronary artery disease, etiology of ICU admission, Acute Physiology and Chronic Health Evaluation II score, Model for End-Stage Liver Disease score, and mechanical ventilation, age _ 75 years remained significant for in-hospital mortality (hazard ratio 2.61, 95% confidence interval 1.27e5.39, p ? 0.009) and 6-month mortality (hazard ratio 2.34, confidence interval 1.16 e4.70, p ? 0.017). Conclusion: During ICU stays, old age does not have adverse effects on ICU mortality, ventilator-free days, ICU days, or ICU-free days in cirrhotic patients (either compensated or decompensated cirrhosis). After ICU discharge, age _ 75 years is an independent prognostic factor for in-hospital mortality and 6-month mortality in patients with decompensated cirrhosis. |
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