頁籤選單縮合
題 名 | Preparation and Characterization of Cetirizine Intercalated Layered Double Hydroxide and Chitosan Nanocomposites |
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作 者 | Kamellia Nejati; Hassan Keypour; Parvaneh Delir Kheirollahi Nezhad; Zolfaghar Rezvani; Karim Asadpour-Zeynali; | 書刊名 | Journal of the Taiwan Institute of Chemical Engineers |
卷 期 | 53 2015.08[民104.08] |
頁 次 | 頁168-175 |
分類號 | 440.34 |
關鍵詞 | Cetirizine; Zn-Al layered double hydroxide; Chitosan; Intercalation; Coprecipitation; |
語 文 | 英文(English) |
英文摘要 | The syntheses and characterization of Zn–Al layered double hydroxide (LDH) and chitosan nanocomposits are reported in the present paper. By increasing chitosan concentration, the crystallite growth is inhibited in both directions a and c. Afterward, cetirizine-intercalated LDH was synthesized. According to XRD patterns, increase in basal spacing indicated that cetirizine anions were intercalated into LDH. In-vitro drug release experiments have been investigated. On the basis of the release profiles, it was found that increase in chitosan concentration causes in decrease in drug release rate. Therefore, chitosan concentration can be adjusted to control the rate of the drug release. |
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