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相關文獻
- Hyperkalemia Associated with Prolonged Magnesium Sulfate Administration in Preeclampsia
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頁籤選單縮合
題名 | Hyperkalemia Associated with Prolonged Magnesium Sulfate Administration in Preeclampsia=妊娠毒血症患者長期使用MgSO₄併發高血鉀症 |
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作者 | 陳鈺緯; 林石化; 陳漢湘; 孫芳如; 吳志仁; Chen, Yu-wei; Lin, Shih-hua; Chen, Han-hsiang; Sun, Fang-ju; Wu, Chih-jen; |
期刊 | 臺灣腎臟醫學會雜誌 |
出版日期 | 20100300 |
卷期 | 24:1 2010.03[民99.03] |
頁次 | 頁9-15 |
分類號 | 417.345 |
語文 | eng |
關鍵詞 | 高血鎂; 高血鉀; 子癲前症; 硫酸鎂; Hyperamgnesemin; Hyperkalemia; Preeclampsia; Magnesium sulfate; |
中文摘要 | 背景:雖然硫酸鎂(MgSO4)已經被有效的利用在治療子癲前症,但因其長期使用所可能誘發的高血鉀則尚未被仔細確認過。因此我們進行此一回朔性之研究,以評估患有子癲前症之婦女在長期使用硫酸鎂時,血清中鉀離子之變化。方法:我們收集了前後三年,總共587位患有子癲前症並使用硫酸鎂的患者,在排除了資料不齊全、病患本身有腎功能不全、病患有急性腎衰竭以及病患使用腎毒性藥物等,總共21位進入分析。分析項目主要包括使用硫酸鎂前後生化數據等變化。結果:在使用硫酸鎂後患者之血清鉀離子有明顯上升的情況,從4.1±0.1 to 4.9±0.1mEq/L(P<0.001),同時這些患者也都有明顯高血鎂(6.5±0.3mg/dL)及低血鈣之情況(6.7±0.2mg/dL)。21位患者中有9位患者之血清鉀離子高於5.0mEq/L(mean, 5.4±0.2mEq/L)。而血清鉀離子上升的幅度則與使用硫酸鎂所累積的劑量呈現正相關(r=0.66, P=0.027)。結論:在子癲前症患者長期使用硫酸鎂有可能造成血清鉀離子明顯的上昇,同時上升的幅度與使用的劑量成正比。 |
英文摘要 | Background: Although magnesium sulfate (MgSO4) has been effectively employed to treat toxemia, hyperkalemia associated with its prolonged administration has not been well recognized. We reviewed retrospectively the records of women with preeclampsia who received prolonged MgSO4 administration to assess serum potassium (K+) levels. Methods: Over a 3-year period, 587 women with preeclampsia were treated with MgSO4. Excluding patients with pre-existing renal insufficiency, acute kidney injury, and those who had treatment with nephrotoxic agents, only 21 patients had had serum magnesium and K+ levels measured both before and after MgSO4 administration. Results: Among the 21 subjects, there was a significant increase in mean serum K+ concentration before and during MgSO4 infusion, from 4.1 ± 0.1 to 4.9 ± 0.1 mEq/L (P<0.001). In addition, there was significant hypermagnesemia (6.5 ± 0.3 mg/dL) and hypocalcemia (6.7 ± 0.2 mng/dL) during treatment. Nine of the 21 patients had serum K+ concentrations exceeding 5.0 mEq/L (mean, 5.4 ± 0.2 mEq/L). A positive correlation was found between the increase in serum K+ concentration and the cumulative MgSO4 dose (r=0.66, P=0.027). Conclusion: Prolonged MgSO4 therapy in preeclampsia may result in a significant increase in serum concentration in a dose-response manner. |
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