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題名 | Protective Effect Against Focal Cerebral Ischemia Injury in Acute Phase of a Novel Invasive Device for Regional Hypothermia= |
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作者 | Chang, Ya-pei; Liao, Pen-ting; Shen, Ein-yiao; Liu, I-hsuan; |
期刊 | Journal of the Chinese Medical Association |
出版日期 | 20150100 |
卷期 | 78:1 2015.01[民104.01] |
頁次 | 頁67-75 |
分類號 | 415.92 |
語文 | eng |
關鍵詞 | Brain ischemia; Hypothermia; Middle cerebral artery infarction; Stroke; |
英文摘要 | Background Systemic hypothermia is considered beneficial to stroke patients. However, many complications ensue. The aim of this study was to evaluate the effect of a new invasive regional cooling device in cerebral ischemic injury in a rat model. Methods After a pilot study confirming the efficiency of the cooling device, 15 adult male Sprague–Dawley rats, weighing 300–400 g, were randomly assigned into three groups: cooling device applied at 14°C and at 26°C, and a sham group. Focal cerebral ischemic injury was achieved by electrocauterization of the left middle cerebral artery through craniectomy and temporal occlusion of both common carotid arteries for 3 hours. Within 30 minutes after the end of ischemic injury, the cooling device was inserted into the rat brain through a stereotactic frame to provide regional hypothermia for 2 hours. The rats were sacrificed immediately after the 2-hour regional hypothermia. Results Although triphenyltetrazolium chloride staining showed smaller ischemic lesions in both the 26°C and 14°C groups compared to the control group, Fluoro Jade C staining showed no neuroprotective effects in the rostrum cerebral cortex in both groups. However, both triphenyltetrazolium chloride and Fluoro Jade C staining indicated significant beneficial effects in the caudal cerebral cortex in rats with cooling device applied at 26°C compared to the 14°C and control groups. Conclusion Our findings indicated that the device can effectively achieve regional hypothermia and could be beneficial for patients with cerebral ischemia during the acute phase. |
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