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| 題 名 | 探討Lamotrigine使用之合理性=Clinical Use of Lamotrigine--From Drug Injury Relief |
|---|---|
| 作 者 | 遲蘭慧; 巫蕙宜; 翁菀菲; 沈君儀; | 書刊名 | 藥學雜誌 |
| 卷 期 | 29:2=115 2013.06[民102.06] |
| 頁 次 | 頁30-34 |
| 分類號 | 418.21 |
| 關鍵詞 | 癲癇; 雙極性疾患; Lamotrigine; Drug relief; Adverse drug reactions; Severe cutaneous reaction; SCR; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | Lamotrigine 為新一代抗癲癇藥,已廣泛使用於治療癲癇及雙極性疾患之單一或附屬療法 (add-on therapy),一般認為本藥較傳統抗癲癇藥 (如:carbamazepine、phenytoin 及 phenobarbital) 安全,但上市後使用經驗顯示其導致之皮疹不良反應及其程度為應值得重視之議題。 藉由歷年藥害救濟審議案件結果顯示,與 lamotrigine 相關之藥害均為嚴重皮膚不良反應,且研究發現此不良反應之發生與併用藥品 (藥品-藥品交互作用) 及起始劑量過高有關係。故本研究將針對該藥疑似導致不良反應而申請藥害救濟案例加以分析及整理,以瞭解國人 lamotrigine 使用情形及不良反應之型態。 |
| 英文摘要 | Lamotrigine (LTG), a newer antiepileptic drug (AED), has been approved as mono-therapy and add-on therapy in partial and generalized seizures and bipolar disorders. AEDs associated with increased risk of severe cutaneous reaction (SCR) including carbamazepine, phenytoin and phenobarbital are well known. Based on post-marketing surveillance data, the incidence of LTG associated allergic skin reaction occurs near 10% of patients and some cases leads to life-threatening SCR. In the past decades, lamotrigine has become the important medication attributed to the drug relief payment for severe adverse drug reactions (ADRs) in Taiwan. We analyzed and reported the results of drug injury relief applications associated with LTG to determine whether and how the risk of serious skin reactions should be minimized in practice. The results did indicate that serious cutaneous ADRs appeared to be linked with too large starting doses without titration and with concurrent use of valproate inappropriately. |
本系統中英文摘要資訊取自各篇刊載內容。