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題名 | Clinical Experience of One-Year Icodextrin Treatment in Peritoneal Dialysis Patients=使用ICODEXTRIN腹膜透析液的一年臨床經驗 |
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作者 | 許君碩; 蘇鍵育; 張智鴻; 許國泰; 林景坤; 廖上智; 陳德全; 李志雄; 陳靖博; 鄭本忠; 李建德; Hsu, Chun-shuo; Su, Chien-yu; Chang, Chih-hung; Hsu, Kao-tai; Lam, King-kwan; Liao, Shang-chih; Chen, Te-chuan; Lee, Chih-hsiung; Chen, Jin-bor; Cheng, Ben-chung; Lee, Chien-te; |
期刊 | 臺灣腎臟醫學會雜誌 |
出版日期 | 20100900 |
卷期 | 24:3 2010.09[民99.09] |
頁次 | 頁133-137+181 |
分類號 | 415.816 |
語文 | eng |
關鍵詞 | 腹膜透析; 代謝反應; 脫水量; Icodextrin; Peritoneal dialysis; Metabolic effects; Ultrafiltration; |
英文摘要 | Background: Icodextrin is a glucose polymer dialysate of high molecular weight indicated specifically for use as an alternative during the long-dwell exchange in peritoneal dialysis (PD). To investigate its influence on PD therapy, a one-year observational study was conducted. Methods: We evaluated the effects of icodextrin PD solution in 34 stable PD patients after a mean treatment period of 16 months. Their blood pressure, body weight, serum albumin, lipid profile, electrolyte, amount of ultrafiltration (UF), peritoneal equilibration test (PET), total dialysis clearance (weekly Kt/V and creatinine clearance), residual renal function at baseline, and after 6 and 12 months of icodextrin treatment were recorded and compared. Adverse treatment-related reactions were also collected. Results: Icodextrin indwell achieved an average UF amount of 621 ± 286 mL per bag. The body weight, blood pressure, and daily UF amount did not change significantly after usage of icodextrin. Within a one-year period, there was a significant reduction in weekly creatinine clearance and amount of urine. nPCR was increased significantly at 6- and 12-month intervals. The fasting serum glucose and triglyceride levels decreased at 6-month interval but only glucose level continued to decline at 12-month interval. Mild elevation of serum potassium level was noted after icodextrin treatment. Most patients’ PET remained essentially the same after icodextrin use. No major adverse reaction was reported. Conclusion: Icodextrin-based peritoneal solution could lower plasma sugar and triglyceride levels. It also improved protein intake and increased serum potassium level. There was no significant change in peritoneal transport function during one-year icodextrin treatment. |
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