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頁籤選單縮合
題 名 | 抗生素封存療法用於導管感染的療效探討=Antibiotic Lock Therapy in Clinical Use |
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作 者 | 林佩姿; 鄭奕帝; 王芙容; | 書刊名 | 藥學雜誌 |
卷 期 | 27:3=108 2011.09[民100.09] |
頁 次 | 頁100-106 |
分類號 | 418.281 |
關鍵詞 | 導管相關感染; 抗生素封存; Catheter related infection; Antibiotic lock; |
語 文 | 中文(Chinese) |
中文摘要 | 中央靜脈導管的使用已成為整體醫學治療的一部分,對於亟需仰賴導管治療的患者,當發生導管相關感染,為降低導管的移除率,此時在治療策略尚可選擇抗生素封存療法。但當導管感染為複雜性的膿腫感染、有化膿性血栓靜脈炎、心內膜炎及骨髓炎時,不論導管使用時間長短,皆建議將導管移除,並以全身性抗生素治療。封存溶液在配置及使用時需考慮到相容性及安定性問題。臨床上已有許多用於治療導管相關感染的案例,但大多數研究多非隨機分配、雙盲,且觀察樣本數不足,缺乏設計優良的研究加以探討,且抗生素封存治療的時間在不同研究差異很大,多半和全身性抗生素一起併用,鮮少單獨使用於導管感染的患者。目前仍有一些尚未解決的問題,因此並沒有明確的臨床使用規範。未來可以在有疑義處做深入研究及探討,補強臨床證據,制定標準的治療規範及建議,以嘉惠更多病患。 |
英文摘要 | Central vein catheters had been become one part of all medical therapy especially for highly needed catheter patient. When patient suffered from catheter-related infection, we may have another choice which is antibiotic lock therapy to reduce catheter-removing rate. Removing infected-catheter and treating with antibiotic are the best strategy, when infections are complicated including suppurative thrombophlebitis, endocarditis and osteomyelitis whether how long the catheters indwell. However, preparation of lock solution should consider the stability and compatibility. We have a lot of clinical experiences which use antibiotic lock therapy to control catheter-related infection. But they usually did not well design to explore the efficacy and related-issues. The treatment duration are variable between different studies, and antibiotic lock therapy is usually combination with systemic antibiotic, rarely use alone. We still have some doubt about antibiotic lock therapy now, therefore there is no definitely clinical practice guidelines to tell medical staffs how to manage catheter-related infection by this way. Future we could do more research and explore on doubtful things about antibiotic lock therapy, and strength the clinical evidence to make a practice guideline. |
本系統中英文摘要資訊取自各篇刊載內容。