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頁籤選單縮合
題名 | 疑似Thalidomide引起心搏徐緩=Suspected Thalidomide Induced Bradycardia |
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作者 | 吳佳璇; 蘇慧真; 王慧瑜; Wu, Chia-hsuan; Su, Hui-chen; Wang, Hue-yu; |
期刊 | 藥學雜誌 |
出版日期 | 20121200 |
卷期 | 28:4=113 2012.12[民101.12] |
頁次 | 頁106-110 |
分類號 | 418.31 |
語文 | chi |
關鍵詞 | 心搏徐緩; 低血壓; 多發性骨髓瘤; Thalidomide; |
中文摘要 | Thalidomide早期被用來作為鎮靜安眠的藥品,因為造成孕婦產下畸胎的悲劇而被要求全面下市。近年來許多研究證實, thalidomide具有抗腫瘤活性,而重新被醫藥界重視。此案例為 68歲男性使用 thalidomide治療多發性骨髓瘤五個多月後,疑似因 thalidomide導致心搏徐緩及低血壓而進入加護病房接受急救的案例報告。藉由搜尋相關文獻探討 thalidomide引起心搏徐緩和低血壓相關機轉、處理原則及可能潛在的藥物交互作用,藉此提醒臨床醫護人員遇到類似案例的病人,需加強衛教其藥品可能產生的相關副作用與注意事項。 |
英文摘要 | We reported a case of suspected thalidomide induced bradycardia and hypotension. A 68-year-old male with multiple myeloma treated with the combination therapy of thalidomide, melphalan and prednisolone about 6 months. Upon admission, he suffered from sinus bradycardia and hypotension then admitted to ICU for further care. After discontinuing the suspected drug, thalidomide, giving atropine and fluid challenge, the patient's vital signs returned to normal status then discharged home. Under the impression of thalidomide-induced sinus bradycardia, we reviewed literatures to learn that despite low incidence reported adverse effects of bradycardia of thalidomide, it appears to be an important one to report and discuss. We also hope to advise patients to notice this kind of side effects in the clinical setting, so they can get medical attention in time. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。