頁籤選單縮合
題名 | 阿斯匹靈於慢性心臟衰竭病人的療效探討:實證醫學之應用解析=An Evidence-based Practice of Aspirin for Chronic Heart Failure Patient |
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作者 | 林宗坤; 張秉宜; 林利珍; | 書刊名 | 藥學雜誌 |
卷期 | 26:4=105 2010.12[民99.12] |
頁次 | 頁17-21 |
分類號 | 418.22 |
關鍵詞 | 實證醫學; 抗血栓藥物; Evidence-based practice; Antithrombotic agent; |
語文 | 中文(Chinese) |
中文摘要 | 抗血栓藥物在慢性心臟衰竭病人的使用一直沒有定論,為了能瞭解抗血栓藥物中阿斯匹靈是否適合用在有慢性心臟衰竭病人的療效與安全性,本文藉著實證研究的步驟,找到 WASH與WATCH兩個證據等級皆為 1b的臨床試驗文獻,發現兩個研究結果都指出,在心臟衰竭病人使用阿斯匹靈時,會加重病人因心臟衰竭所導致的住院發生率,將 WASH研究結果的數據以實證方法計算後,每 6個使用阿斯匹靈藥物的心臟衰竭病人( NNH=6),在平均治療 27個月以後,可能會有一個病人因使用阿斯匹靈導致住院的發生。運用實證醫學的技巧與方法歸納出結論:在心臟衰竭的病人中使用阿斯匹靈可能會加重病人因心臟衰竭所導致的住院發生率,所以不建議阿斯匹靈列為心臟衰竭病人的例行治療藥物。 |
英文摘要 | The roles of antithrombotic therapy for patients with chronic heart failure have long been debated. In order to further understand the benefits and risks of Aspirin used in antithrombotic therapy for heart failure patients, this paper had critically reviewed two literatures of individual random clinical trials, WASH and WATCH studies, based on the evidence-based study methods including asking, acquiring, appraising, applying and auditing. In both of WASH and WATCH studies, the results had showed that Aspirin might increase the hospitalization rates in patients with heart failure. Furthermore, in WASH study, the additional hospitalization (NNH) was calculated as one in every six patients with heart failure after 27 months therapy. Therefore, the conclusion of this study would suggest that Aspirin should not be used as a standard regimen for patients with heart failure. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。