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題 名 | 選擇性基因定型資料的韋伯迴歸分析=Weibull Regression Analysis for Selective Genotyping Data |
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作 者 | 曾信嘉; 鍾易叡; | 書刊名 | 作物、環境與生物資訊 |
卷 期 | 7:2 2010.06[民99.06] |
頁 次 | 頁117-124 |
分類號 | 362.6 |
關鍵詞 | 選擇性基因定型; 檢定力; 加速失敗時間模式; QTL定位; 截切選取; Selective genotyping; Power; Accelerated failure time model; QTL mapping; Truncated selection; |
語 文 | 中文(Chinese) |
中文摘要 | 摘要 在定位數量性狀基因座(quantitative trait loci, QTL)上,選擇性基因定型(selective genotyping,只取表現型數值高或低的樣本來鑑定基因型)是一種符合成本效益的方式,而 且在標識基因與性狀之關聯性檢定中,此方式能提供大部分的檢定力(power)。然而,大多 選擇性基因定型有關QTL 定位的統計方法,係建議在常態且完整觀察的表現型下使用。當 表現型為失敗時間或存活時間的資料時,常會有偏斜分配與失去追蹤等問題,使得這些方 法將無法使用。在本研究中,使用加速失敗時間模式(accelerated failure time model)描述 不同基因型對存活性狀之影響,並在選擇性基因定型設計下,針對有被鑑定基因型之個體 資料,發展有母數(parametric)推論以估計迴歸參數。最後,透過一些模擬研究來評估所建 議方法之表現。 |
英文摘要 | ABSTRACT Selective genotyping (i.e., genotyping only a selected sample with the high or low phenotypic values) is one of the cost-effective ways in mapping quantitative trait loci (QTLs) and can provide most of power for a marker-trait association test. However, most of statistical methods for QTL mapping under selective genotyping are proposed for normally distributed and completely observed phenotypes. These approaches may not be used when the phenotype is the failure time or survival time, which has a skewed distribution and is often loss to follow-up. In this study, using the accelerated failure time model for the effects of genotypes on survival trails and the parametric inference was developed for estimating regression parameters under selective genotyping designs by using only the information of genotyped individuals. Finally, some simulation studies were presented to evaluate the performance of the proposed methods. |
本系統中英文摘要資訊取自各篇刊載內容。