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題 名 | Cytotoxic constituents of Hydrangea Angustipetala on Human Gastric Carcinoma Cells=狹葉八仙花對胃癌細胞之毒性成分 |
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作 者 | 謝清睿; 游璧如; 陳立耿; 趙淑妙; 張君照; 王靜瓊; | 書刊名 | Botanical Studies |
卷 期 | 51:1 2010.01[民99.01] |
頁 次 | 頁45-51 |
分類號 | 414.34 |
關鍵詞 | 凋亡; 狹葉八仙花; 擔癌鼠; 虎耳草科; Apoptosis; (+)-febrifugine; Hydrangea angustipetala; P-388D1-CDF1; mice; Trans-3-p-coumaroylquinic acid; Saxifragaceae; |
語 文 | 英文(English) |
中文摘要 | 狹葉八仙花(虎耳草科)生長在北台灣山區,常用於抗瘧疾的民間藥。本研究採集葉部,利用 70% 丙酮均質萃取後,配合細胞毒性分析,追蹤分離其活性成分。以40% 甲醇沖提Diaion HP-20 管柱之沖提物(D40M),可抑制P-388D1 細胞之生長,並可延長P-388D1 擔癌鼠之生命。繼而從D40M 沖提物中,分離得到 (+)-febrifugine (1) 及 trans-3-p-coumaroylquinic acid (2) 之天然物,並皆具有誘導AGS 及SNU-1 胃癌細胞凋亡之作用。而且(+)-febrifugine 的細胞毒性比trans-3-p-coumaroylquinic acid 強,(+)-febrifugine 加入AGS 及SNU-1 胃癌細胞48 小時,其抑制 50% 濃度分別為0.17 及0.05 µg/ml 。此兩者亦可降解AGS 及SNU-1 胃癌細胞中PARP 及 pro-caspase 3 ,當加入 caspase-3-specific 抑制劑時,此兩個天然物所引起之細胞毒性將可被緩解。因此推測,此兩個天然物所引起之細胞毒性可能是透過活化caspase 3 之路徑。而 (+)-febrifugine 將可作為開發抗癌藥時的起始物。 |
英文摘要 | Hydrangea angustipetala Hayata (Saxifragaceae) is an anti-malaria folk medicine and grows in mountains of northern Taiwan. The leaves of H. angustipetala were extracted with 70% acetone and column chromatography was combined with cytotoxic bioassay-guided fractionation to isolate the cytotoxic compounds. The Diaion HP-20 column 40% MeOH eluted fraction (D40M) of H. angustipetala inhibited the growth of P-388D1 cells in vitro and prolonged the survival days of P-388D1-bearing CDF1 mice. Furthermore, (+)-febrifugine (1) and trans-3-p-coumaroylquinic acid (2) were isolated from the D40M, and both compounds induced apoptosis in AGS and SNU-1 cells. However, the cytotoxicity of 1 was stronger than 2 and IC50 values of 1 were 0.17 and 0.05 µg/ml in AGS and SNU-1 cells after treatment for 48 h, respectively. The two compounds both induced decreases in PARP and pro-caspase 3 of AGS and SNU-1 cells, and pre-treatment of cells with a caspase-3-specific inhibitor reduced cytotoxicity by 1 and 2 in AGS and SNU-1 cells. We suggested that the activation of caspase-3 may provide a mechanistic explanation for their (1 and 2) cytotoxic effects in AGS and SNU-1 cells. (+)-Febrifugine was a good lead compound as development an anticancer drug. |
本系統中英文摘要資訊取自各篇刊載內容。