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題 名 | The Direct Cardiac Effect of Propofol on Intact Isolated Rabbit Heart=Propofol對離體兔子心臟的直接作用 |
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作 者 | 陳威豪; 李昭然; 洪國全; 葉富欽; 曾稼志; 蕭介民; | 書刊名 | 麻醉學雜誌 |
卷 期 | 44:1 民95.03 |
頁 次 | 頁19-23 |
分類號 | 416.262 |
關鍵詞 | 心室壓力; 左心室功能; 心肌收縮; 心率; Propofol; Ventricular pressure; Ventricular function, left; Myocardial contraction; Heart rate; |
語 文 | 英文(English) |
中文摘要 | 背景:Propofol在臨床使用日漸普及,但其低血壓作用仍是令人擔心的問題;近年來雖然已有多篇論文探討propofol低血壓之機制,可能機制包括周邊阻力與心收縮力的抑制;但活體研究通常不易控制其他因子,如前負荷與血管阻力,甚至於可能受神經或賀爾蒙等影響致無法完全獨立探討;而離體模式則大部份以細胞為單位;目前以完整離體心臟模式探討propofol濃度對心收縮力之影響之報告仍少。本研究以兔子的完整離體心臟模式(modified Langendorff Model),探討在不同濃度的propofol灌注下對心臟收縮力及心率的直接作用。同時探討回復正常心率對心臟收縮力之影響。方法:第一階段(N=11)為利用兔子的離體心臟,藉由離體心臟冠狀動脈循環灌注不同濃度的propofol(1, 5, 25, 50 mg/L)後,測量其左心室的壓力及收縮力(dp/dt單位時間內的壓力變化來表示)與心率。第二階段(N=7)除了給予不同濃度的propofol灌注外,另外在完成不同濃度的propofol灌注後,將兔子的心臟以心博控制器調整心率回基礎值,穩定後再紀錄左心室的壓力與收縮力,比較控制心率前後的差異。結果:左心室的壓力與收縮力與心率隨著給予propofol的濃度增加而下降,尤其在給予高濃度(25和50mg/L)的情況下,達到顯著意義(P值小於0.05)。將兔子的心博速節律控制回基礎值後,發現左心室的壓力與收縮力並未跟著恢復。結論:Propofol隨著濃度的提高,心臟壓力及收縮力的抑制作用也會增強。另外,在給子propofol高濃度下,也確實會降低心率。但,回復心率並無法回復心臟收縮力。 |
英文摘要 | Background: The objective of the current study was to determine the direct effect of propofol on intact isolated rabbit heart using the modified Langendorff model. Methods: Eighteen rabbits were decerebrated under light ether anesthesia. Their hearts were then excised and prepared pursuant to the modified Langendorff model. Left ventricular pressure, left ventricular contractility (dp/dt) and heart rate were recorded in the absence of propofol and in the presence of propofol of four different concentrations (1, 5, 25, 50 mg/L). In one group of hearts (N=11) the heart rate was not paced. In another group of hearts (N=7), the hearts were paced (during the control period and in propofol of each concentration) at a rate slightly higher than control rate and then allowed to revert to original state; pressure and contractility were measured and taken at both paced and unpaced rates. Results: In the unpaced group of hearts, a significant dose-dependent, negative effect on both left ventricular pressure and contractility was found at the two higher propofol concentrations (25 and 50 mg/L). A significant heart rate decrease was also revealed at these two concentrations. In the paced group, the left ventricular pressure and dp/dt also decreased significantly at higher propofol concentrations, and they did not return toward control values even though the heart was paced at the baseline unpaced rate. Conclusions: Propofol depressed left ventricular pressure and contractility and heart rate in a dose-dependent manner at higher concentrations. These negative cardiac effects were independent of changes in heart rate. |
本系統中英文摘要資訊取自各篇刊載內容。