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題名 | A Case of Gastrointestinal Stromal Tumor with Hyperinsulinemic Hypoglycemia=胃腸道基質瘤合併高胰島素血性低血糖症 |
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作者 | 何競輝; 林家立; 王宗熙; 張榮和; 陳漢明; Hall, King-fair; Lin, Chia-li; Wang, Tsung-hsi; Chang, Rung-ho; Chen, Han-ming; |
期刊 | 長庚醫學 |
出版日期 | 20080100、20080200 |
卷期 | 31:1 2008.01-02[民97.01-02] |
頁次 | 頁107-111 |
分類號 | 415.138 |
語文 | eng |
關鍵詞 | 低血糖; 胃腸道基質瘤; 類胰島素生長因子; 非胰島細胞瘤合併低血糖症; Hypoglycemia; Gastrointestinal stromal tumor; Insulin-like growth factor I; Non-islet cell tumor with hypoglycemia; |
中文摘要 | 胃腸道基質瘤是一種不常見的胃腸道惡性腫瘤,其多變之臨床表現、內分泌學之病因病理、惡性轉移的變化、不良的預後及在腫瘤學上之基因突變,都有其特別之處。臨床上極少基質性瘤是以低血糖表現。我們將在此做一病例之報告,為一胃腸道基質瘤合併高胰島素血性低血糖症,其臨床上甚為罕見地以神經學症狀表現。 |
英文摘要 | Gastrointestinal stromal tumor (GIST) is an uncommon malignant tumor that has recently been drawn to the attention of clinicians because of the protean clinical spectrum, endocrinological pathogenesis, aggressive metastatic features, poor prognosis, oncogenic tyrosine kinase receptor mutation and its brilliant revolutionized inhibitor imatinib. However, very few cases of GIST and hypoglycemia have been reported worldwide and they are usually associated with normal or low insulin levels. Here, we report on a rare case of GIST with postabsorptive hypoglycemia, extraordinary hyperinsulinemia and low insulin-like growth factor I (IGF-I). Its unusual neurological presentation made its diagnosis very difficult. After a complete resection, the symptoms diminished. We point out the unusual endogenous hyperinsulinism, clinical features and postulate possible mechanisms. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。