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題名 | Mondia whitei L. (VUKA) 水萃物連續餵飼大鼠7天之生理安全及雄性生殖功能評估=Physiological Safety and Reproductive Evaluations on A Seven-day Consecutive Feeding of Mondia whitei L. (VUKA) Water Extract to Male Rats |
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作者 | 郭肇凱; 廖俊旺; 張隆仁; 陳榮五; Kuo, Xhao-kai; Liao, Jiunn-wang; Chang, Long-zen; Chen, Yung-wu; |
期刊 | 臺中區農業改良場研究彙報 |
出版日期 | 20070600 |
卷期 | 95 2007.06[民96.06] |
頁次 | 頁37-48 |
分類號 | 418.5 |
語文 | chi |
關鍵詞 | 連續7天餵食; 大白鼠; 精蟲; 荷爾蒙; Mondia whitei; VUKA; 7-day consecutive feeding; Rats; Sperm; Hormone; |
中文摘要 | 本研究主要探討Mondia whitei L. (VUKA)水萃冷凍乾燥粉末連續餵飼雄性大鼠7天之生理安全及睪丸生殖功能評估,劑量選擇為100、500及1,000 mg/kg BW,對照組則為蒸餾水,每日以胃管餵飼大鼠連續7天。結果顯示處理組之雄性大鼠體重、心、肝、腎、脾、睪丸與副睪等臟器重量與對照組比較均無明顯差異。檢查血清酵素,VUKA水萃冷凍乾燥粉末可降低肝功能之麩氨酸氨基轉氨酶(aspartate aminotransferase, AST)與麩氨酸丙酸轉氨酶(alanine aminotransferase, ALT);對麩氨基轉氨酶(γ-glutamyltranspeptidase, GGT)、鹼性磷酸酶(alkaline phosphatase, ALP)、乳酸脫氫酶(lactate dehydrogenase, LDH)、膽固醇(cholesterol)、三酸甘油脂(triglyceride)、總蛋白(total protein)、白蛋白(albumin)、尿酸(uric acid)、鈉離子(sodium)、鉀離子(potassium)氯離子(chloride)及鈣離子(calcium)濃度等項目均無影響,但中與高劑量處理組白蛋白與球蛋白比例(albumin/globulin ratio, A/G ratio)則有明顯降低;高劑量處理組之腎功能血清中尿素氮(blood urea nitrogen)值則有顯著性上升,但低與中劑量處理組之肌氨酸(creatinine)則有顯著性下降。但VUKA水萃冷凍乾燥粉末均不會造成上述體內重要臟器之明顯肉眼及組織病理變化。在生殖功能評估方面,各處理組之精蟲濃度相較於對照組有顯著性增加,但對精蟲活動力及畸形率則無影響。分析睪丸組織及血清睪固酮(testosterone)、雌激素(estrodial)及黃體素(pregesterone)荷爾蒙變化,除雌激素因微量無法被偵測出來外,各處理組對雄鼠睪固酮含量均無影響,但血清中黃體素含量則呈劑量與反應之顯著性降低作用。綜合以上結果顯示,VUKA水萃冷凍乾燥粉末續餵飼雄性大鼠7天並無毒性作用,亦不影響雄性生殖功能,但對降低雄鼠黃體素之生理作用,仍有待進一步探討。 |
英文摘要 | The objective of this study was to evaluate physiological safety and reproductive function for a 7-day consecutive feeding of VUKA freez-dried water extract in Sprague Dawely (SD) male rats. The VUKA extract was administrated daily by gavage to each group at different doses of 0, 100, 500 and 1000 mg/kg BW for 7 days. Body and organ weights of different treatments had no significant difference (p>0.05) from control. Serum biochemical changes in liver such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in treated rats showed significant decreases (p<0.05) as compared with of the control. Besides, albumin/globulin ratio (A/G ratio), blood urea nitrogen (BUN) and creatinine were comparable to those of control. But, the levels of γ-glutamyltranspeptidase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), cholesterol, triglyceride, total protein (TP), albumin, uric acid, sodium, potassium, chloride and calcium in serum had no significant differences (p>0.05) with those of the control. There were no significant lesions of testis and epididymis founded at gross and histopathological observation in the treated rats. For reproductive function versus control, concentrations of spermatozoa in all treatments showed significant increases (p<0.05), while progesterone in serum in all treatments had significant decrease (p<0.05). The results showed that feeding of VUKA freeze-dried water extract in male rats for 7 days had no toxic effects and did not affect the reproductive function of male rats. Further study will be carried out to find the phenomenon of lower progesterone value in treatment. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。