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題名 | 常見口腔粘膜病灶與正常口腔粘膜之介白質-1β含量之研究= |
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作者 | 林聰勝; 謝天渝; |
期刊 | 中華民國口腔顎面外科學會雜誌 |
出版日期 | 19950900 |
卷期 | 6:2 1995.09[民84.09] |
頁次 | 頁34-42 |
分類號 | 416.94 |
語文 | chi |
關鍵詞 | 介白質-1β; 口腔粘膜下纖維化症; 鱗狀細胞癌; 上皮疣狀增生; |
中文摘要 | Interleukin-lβ( IL-lβ) 是被證實具有多重作用之發炎性介質,其來源細胞達二十多種。它可使發炎細胞易於白血中移動至發炎組織中,也可以調節細胞外基質之合成與分解以及間接造成骨質吸收並抑制骨生成。目前對於IL-lβ之研究多針對體波及培養液中IL-lβ含量之多寡,較少有關於組織塊中IL-lβ總含量之研究。本研究乃利用酵素免疫分析法 (ELISA) 來加以測定口腔粘膜下纖維化症( OSF)、鱗狀細胞癌 (SCC) 及上皮疣狀增生 (VerH) 組織塊中IL-lβ之含量與正常口腔粘膜組織內之IL-lβ含量作統計學土之比較。結果正常口腔粘膜組織、SCC、OSF、 VerH之IL-lβ含量依序為1.07 ± 0.53 pg/mg tissue、4.37 ±0 .87pg/mg tissue、0.76 ± 0.56pg/mg tissue及3.97 ± 1.93 pg/mg tissue。以Mann - Whitney U test 分析顯示正常粘膜與OSF之間無統計上差異 (p>0.05) 而與SCC及VerH之間有差異 (p<0.001)。SCC與VerH之間無統計上差異 ( p>0.05 )。顯示IL-1β在組織塊中總含量與疾病之發炎程度及細胞變性呈現關聯性;另一方面,IL-lβ總含量在OSF的組織中並無明顯變化而且不能依據IL-lβ含量作為疾病嚴重度之參考。 |
英文摘要 | Interleukin-l β (IL-lβ) has been proven to be a multi-effect medium of inflammation. It is a polypeptide and is the principal form of interleukin-l. Its source cells total over twenty and its effects cover both immune cells and non-immune cells. In endothelium, it makes it easier for inflammatory cells to move from the blood to the inflamed tissues. In fibroblast, it can regulate the synthesis and decomposition of extra-cellular matrix. It can also indirectly cause bone absorption and inhibit bone growth. It is therefore evident that IL-lβplays a variety of roles, however, most current research is aimed at investigating the content of IL-1 β in body fluids and single cell culture solution. Research into the total amount of IL-1 β in tissue blocks in more seldom encountered, and there is a particular dearth of research into the total amounts of IL-l βpresent in oral lesions. Therefore, this study used the method of enzyme linked immunosorbent assay (ELISA) to perform a statistical comparison between the amounts of IL-l β present in normal oral mucosa and that present in oral submucous fibrosis (OSF), squamous cell carcinoma (SCC), and verrucous hyperplasia (VerH). The results found that the amounts of IL-1β present in normal oral mucosa, OSF, SCC, and VerH respecitively are 1.071 ± 0.53 pg/mg tissue (mean ± SD), 0.76 ± 0.56 pg/mg tissue, 4.37 ± 0.87 pg/mg tissue, and 3.97 ± 1.93 pg/mg tissue. Listed in descending order, these are SCC VerH, normal, and OSF. Performing a Mann-Whitney U Test shows that there is no significant difference (p>0.05) between the amount of IL-1 β present in normal oral mucosa and oral submucous fibrosis, however there was a significant difference (p<0.001) between the amount of IL-1β present in normal oral mucosa and both squamous cell carcinoma and verrucous hyperplasia. There exists no significant difference between the amount of IL-1β present in SCC and VerH. It can be seen from the above results that the amounts of IL-1β present in SCC and VerH are obviously higher than that of normal oral mucosa and OSF. This shows that there is a correlation between the amount of IL-1β in tissue blocks and both the degree of inflammation and cell transformation. On the other hand, the fact that there is no significant difference between the amounts of IL-1β present in normal oral mucosa and OSF shows that the amount 1L-1 β does not change significantly as the disease progresses. Analysis also shows that the amount of 1L-1βpresent in oral submucous fibrosis tissue blocks in unrelated to the seriousness of the disease. Thus, IL-lβlevels cannot be used to gauge the seriousness of fibrosis. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。