頁籤選單縮合
題 名 | Effects of Orlistat and Its Relationship with Nitric Oxide in the Small Intestinal Mucosa |
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作 者 | Caner, Metin; Dogruman, Husniye; Taskιn, Elif; Kandil, Aslι; Demirci, Cihan; | 書刊名 | 中國生理學雜誌 |
卷 期 | 48:4 民94.12 |
頁 次 | 頁217-222 |
分類號 | 418.2 |
關鍵詞 | Orlistat; Dexamethasone; Nitric oxide; |
語 文 | 英文(English) |
英文摘要 | Nitric oxide (NO) is known to be a messenger molecule that plays an important role in physiological and pathological conditions. It is synthesized by an enzyme called nitric oxide syntheses (NOS). Inducible NOS (iNOS), one of the three isomers of NS, has both protective and toxic properties. In this study, the role of NO has been evaluated by gastrointestinal symptoms induced by orlistat which is used in obesity treatment. Orlistat was given to Wistar rats with and without iNOS inhibition. The effects of orlistat and inhibition of NOS were studied. Glucose, urea, alanine transaminase (ALT), and gamma glutamil transpeptidase (GGT) were decreased after short- and long- term orlistat application. Dexamethasone increased level of these enzymes. Cholesterol and triglyceride were increased in all experimental groups than the controls. This increment was more severe in animals received orlistat and dexamethasone together. Small intestinal tissue also were researched hitologically and NADPH-diaphorase (NADPH-d) hitochemistrically. Orlistat caused histological damages in brush border membranes, connective tissues of villi, and lymphocyte migration also increased. Dexamethasone treatment prevented these damages partially while orlistata increased the NOS distribution I the tissue sections. Dexamethasone, which is an iNOS inhibitor, decreased NADPH-d histochemistry. There was a similar NOS distribution both in the control and orlistata+dexamethasone group. Hence, we concluded that long-term trials with orlistat and similar drugs are needed. |
本系統中英文摘要資訊取自各篇刊載內容。