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題名 | Nм23-H1: A Metastasis-associated Gene= |
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作者 | Tee, Yi-torng; Chen, Gin-den; Lin, Long-yau; Ko, Jiunn-liang; Wang, Po-hui; |
期刊 | Taiwanese Journal of Obstetrics & Gynecology |
出版日期 | 20060600 |
卷期 | 45:2 民95.06 |
頁次 | 頁107-113 |
分類號 | 415.138 |
語文 | eng |
關鍵詞 | High-grade squamous intraepithelial lesion; Kinase suppressor of Ras; Metastasis; Nm23-H1; Nucleoside diphosphate kinase; Squamous cell carcinoma; |
英文摘要 | The protein product ofnm23-H1 gene has activity of nucleoside diphosphate (NDP) kinase, which catalyzes the phosphorylation of nucleoside diphosphates to the corresponding nucleoside triphosphates. Reductions n nm23 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas. On the contrary, high levels of nm23 gene expression are noted n the advanced stage of thyroid carcinomas and associated with significant reductions in survival for neuroblastoma and osteosarcoma patents. Although expression of nm23/NDP kinase is divergent n various malignant tumors, is reduced expression seems to be related to increased metastatic potential n most carcinoma types. However, it is hypothesized that nm23 may play a tissue-specific role, and that different regulatory mechanisms may act in different tumors. In ovarian carcinoma, nm23-H1/NDP kinase may be correlated with some clinicopathologic characteristics. In cervical cancer, nm23-H1 is probably involved n cervical carcinogenesis and correlated with some aggressive parameters. Overexpression of nm23-H1 protein may indicate poor survival for cervical cancer patents. Other than histidine 118 residue (amino acid sequence 118: histidine) concerned with NDP kinase activity of nm23-H1, serine 120(amino acid sequence 120:serine) related activity of histidine-dependent protein phosphotransfer was recently reported to be responsible for its biological suppressive effects. To inhibit metastatic potential, nm23-H1 is also demonstrated to co-immunopreciptate the kinase suppressor of Ras and phosphorylate it, and therefore reduce activation of the extracellular signal-regulated kinase mitogen-activated protein kinase pathway in response to signaling. |
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