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題名 | CK, CK-MB, Troponin-I Levels in Perinatal Asphyxiated Infants during the First Four Hours of Life: A Retrospective Study=CPK, CPK-MB及Troponin-I在周產期窒息新生兒出生4小時內之變化:一回溯性研究 |
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作者 | 李淑婷; 沈仲敏; 那明珠; 柯嘉音; 林隆煌; | 書刊名 | Clinical Neonatology |
卷期 | 13:2 民95.12 |
頁次 | 頁51-54 |
分類號 | 417.517 |
關鍵詞 | 周產期窒息; 新生兒; Perinatal asphyxia; Cardiac enzyme; Multiorgan dysfunction; Hepatic injury; |
語文 | 英文(English) |
英文摘要 | Objective: To compare serum cardiac troponin-I (cTnI), creatine kinase (CK), creatine kinase-MB (CK-MB), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels within the first 4 hours of life in asphyxiated and non-asphyxiated term newborn infants. Methods: This is a retrospective study of asphyxiated term infants (gestational age from 37 to 42 weeks) born at Cathay General Hospital during the study period (January 1, 1995 – December 31, 2005). Ninety five asphyxiated cases and 76 non-asphyxiated cases were enrolled in the study. We classified the study cases into a control group, group Ⅰ (asphyxiated newborns without multiorgan failure) and group Ⅱ (asphyxiated newborns with multiorgan failure). Serum cTnI, CK, CK-MB, AST and ALT levels were measured within the first 4 hours of life. The inclusion criteria for asphyxia consisted of positive history of perinatal fetal distress and at least one of the following features of perinatal asphyxia: (1) arterial pH <7.25; (2) arterial base excess <-8 mmol/L within 4 hours after delivery. Results: CK was not statistically different among the 3 groups. CK-MB, AST and ALT levels were statistically different between any 2 groups within the first 4 hours of life (group Ⅱ>control, group Ⅰ>control, group Ⅱ>group Ⅰ). Further, infants in group Ⅱ had higher concentrations of cTnI than group Ⅰ and the control group. However, cTnI was not statistically different between group Ⅰ and the control group. The CK-MB/CK ratio was only statistically different between group Ⅰ and the control group. Conclusion: CK-MB, cTnI, AST and ALT may be good early indicators of cardiac and hepatic injury within the first 4 hours of life in perinatal asphyxiated newborns. |
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