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題名 | Disrupted Hepatic Adiponectin Signaling Impairs Liver Regeneration of Steatotic Rats=高血脂大鼠的肝臟內脂聯蛋白訊息傳遞阻斷導致肝臟再生能力降低 |
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作者 | 蔡駿逸; 林晏甥; 葉大森; 蔣春福; 張清惠; 陳澤卿; 陳敏夫; Tsai, Chun-yi; Lin, Yann-sheng; Yeh, Ta-sen; Cheong, Chon-folk; Chang, Chin-hui; Chen, Tse-ching; Chen, Miin-fu; |
期刊 | 長庚醫誌 |
出版日期 | 20110500、20110600 |
卷期 | 34:3 2011.05-06[民100.05-06] |
頁次 | 頁248-259 |
分類號 | 415.145 |
語文 | eng |
關鍵詞 | 脂聯蛋白訊息傳遞; 肝臟再生; 肝葉切除; Adiponectin signaling; Liver regeneration; Hepatectomy; |
英文摘要 | Background: Individuals with non-alcohol fatty liver disease (NAFLD) exhibit impaired liver regeneration in a clinical setting and animal experiments. Adiponectin signaling is recognized as an important pathway of lipid metabolism, energy expenditure, anti-inflammation, and cellular proliferation. We herein investigate hepatic adiponectin signaling in dietary steatotic murine models undergoing hepatectomy, which has never been explored. Methods: Sprague-Dawley rats fed with a normal diet (normal), high fat diet (HF), and a methionine-choline deficiency diet for 1 week (MCD 1W) and 5 weeks (MCD 5W), were used. The animals underwent 70% hepatectomy and were thereafter sacrificed at indicated time points. Results: MCD 5W and HF displayed decreased Ki-67 labeling index and restituted liver mass compared to normal. Hepatic adiponectin, as well as TNF-α, of MCD5W and HF were increased compared to normal; whereas adiponectin receptor type 1 (AdipoR1) and adiponectin receptor type 2 (AdpoR2) were reciprocally decreased when compared to normal. PPARα, a downstream molecule of AdipoR2 axis, was decreased in MCD 5W compared to normal. Adenosine monophosphate- activated protein kinase (AMPK), a downstream molecule of AdipoR1 axis, was inactivated soon after hepatectomy in normal; whereas activation of AMPK persisted until day 3 after hepatectomy in MCD 5W and HF. Conclusions: Reciprocal expression of adiponectin and its receptors in steatotic rats represents a unique form of adiponectin signaling disruption, which might be associated with impaired liver regeneration. |
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