頁籤選單縮合
題名 | The Interactions between Paeoniflorin and Veratrine on the Isolated Uterus of Rats= |
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作者 | 蔡輝彥; 林郁茲; 譚思濰; 陳玉芳; Tsai, Huei-yann; Lin, Yuh-tzy; Tan, Tzu-wei; Chen, Yuh-fung; |
期刊 | 中華藥學雜誌 |
出版日期 | 20010600 |
卷期 | 53:3 2001.06[民90.06] |
頁次 | 頁137-146 |
分類號 | 414.5 |
語文 | eng |
關鍵詞 | Paeoniflorin; Veratrine; Rat uterus; Interactions; |
英文摘要 | Some traditional Chinese drugs, such as Paeony root and Veratri radix, are considered to be absolutely incompatible in prescriptions. Therefore, this study attempted to identify the interactions between paeoniflorin and veratrine on the isolated rat uterus. Paeoniflorin (10-4 M) and veratrine (10-8 ~ 10-5 g/mL) did not affect the isolated rat uterus by themselves. They both, however, attenuated the contraction induced by acetylcholine (10-4 M) in a concentration-dependent manner. Paeoniflorin (10-4 M) reversed the inhibition of acetylcholine-induced contraction mediated by 10-6 g/mL veratrine. Furthermore, veratrine (10-4 g/mL) almost completely diminished PGF2a (10-6 M) nduced contractions. The above results suggest that antagonism of paeoniflorin with veratrine might be related to the inhibition of calcium influx via the blockage of calcium channels. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。