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題名 | Prolonged Morphine Treatment Relieves Thermal Hyperalgesia in Rats with Sciatic Nerve Constriction Injury=長期嗎啡治療緩解大白鼠因坐骨神經緊縮傷害所引起之體溫痛覺過敏 |
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作者 | 朱光興; 陳翰平; 康富期; 蔡玉娟; Chu, Koung-shing; Chen, Han-ping; Kang, Fu-chi; Tsai, Yu-chuan; |
期刊 | The Kaohsiung Journal of Medical Sciences |
出版日期 | 20000100 |
卷期 | 16:1 2000.01[民89.01] |
頁次 | 頁20-25 |
分類號 | 418.2132 |
語文 | eng |
關鍵詞 | 嗎啡治療; 大白鼠; 坐骨神經緊縮傷害; 體溫痛覺過敏; Morphine; Neuropathic pain; Chronic constriction injury; CCI; |
中文摘要 | 我們依據Bennett及Xie等最初所提出的老鼠坐骨神經慢性緊縮傷害模式加以修飾 後,觀察經由規律地間斷性長期授予嗎啡藥劑對神經病變性疼痛的影響。經手術在雄性大白 鼠左後肢的生骨神經結紮,而誘發一種神經痛的神經病變,除了坐骨神經結紮外,同樣的手 術步驟也在對側進行。 腳掌對熱縮回反應的時間(PWL)值分別經由術前一天及術後四天已確定產生體溫痛覺過敏後 得到。試驗共分為五組進行,四組試驗組大白鼠在七天中經由皮下每天分別地給予嗎啡 5m、lOmg、l5mg、2Omg,對照組大白鼠則僅接受皮下生理食鹽水注射。在接受治療中的 第5、7、9、11天中,以腳掌對熱縮回反應的時間(PWL)值來評估。結果顯示,在術後第四天 PWL值(=腳掌對熱縮回反應時間)較術前或是在接受Sham術式的肢體均下降50-60%,PWL值 隨嗎啡授予量增加而延長,同時在治療中沒有耐受性產生。這顯示長期閒歇性的使用嗎啡藥 劑是一種可來緩解神經病變性疼痛的可行方式。 |
英文摘要 | We examined the effects of chronic morphine treatment with regular intermittent administration in a modified chronic constriction injury (CCI) model of the rat sciatic nerve originally introduced by Bennett and Xie. A painful neuropathy was induced over the left hind limb with sciatic nerve ligation, and sham surgery was done on the opposite side in male Sprague-Dawley rats. Paw-with-drawal latency (PWL) was obtained one day before surgery (pre-op baseline) and on the fourth day after surgery (post-op) to assure the development of thermal hyperalgesia. Morphine hydrochloride (5,10,15, and 20 mg/kg per day) was subcutaneously administered for 7 days to four experimental groups. The control group received normal saline rather than morphine under the same injection protocol. PWLs were evaluated on days 5, 7, 9, and 11 of the treatment. PWL decreased to 50-60% of the pre-op baseline or sham limb on the fourth day after surgery. Morphine's ability to reverse PWL appeared dose-related, and no tolerance developed during treatment with chronic intermittent administration. This may indicate that prolonged use of intermittently-administered morphine can be a feasible regimen for relief of neuropathic pain. |
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