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題名 | 餵食靈芝菌絲體對小鼠體內抗氧化能力之影響=Effects of Ganoderma Lucidum Mycelium Feeding on the Antioxidant System in Mice |
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作者 | 蕭慧美; 夏彩蘭; Shaw, Huey-mei; Ha, Choi-lan; |
期刊 | 中華民國營養學會雜誌 |
出版日期 | 20060300 |
卷期 | 31:1 民95.03 |
頁次 | 頁17-23 |
分類號 | 418.5 |
語文 | chi |
關鍵詞 | 靈芝菌絲體; 小鼠; 抗氧化酵素; Ganoderma lucidum mycelium; Mice; Antioxidant enzymes; TBARS; |
中文摘要 | 本實驗目的在於探討小鼠餵食靈芝菌絲體後其組織抗氧化情形是否會受到影響。實驗一:將44隻c57BL/6J小鼠分為三組,分別給予含有1%、3%(G1、G3)或不含靈芝菌絲體(C,control)的AIN-93G飼料。實驗二則依飼料中含有5%(GS)或不含靈芝菌絲體(C,control)將小鼠分為兩組,飼養期皆為四週。各組小鼠之終體重未因飼料中靈芝菌絲體含量不同而有所影響。以TBARS值作為組織過氧化指標時,實驗一中各組織的TBARS值於三組間皆無顯著差異,但是在實驗二的結果發現5%的靈芝菌絲體會顯著降低肝臟的TBARS值。肝臟中的Catalase活性(unit/g protein)以G3組顯著高於C組(p<0.05),麩胱甘肽過氧化酶(Glutathione peroxidase,GPx)活性則以G3與G1組皆顯著高於C組(p<0.05);在實驗二的結果發現,雖然G5組的肝臟TBARS值顯著低於C組,但是肝臟中的Catalase、GPx、SOD活性以及維生素E含量於兩組間並無顯著差異。綜合上述結果得知,3%靈芝菌絲體之餵食確實會提升肝臟的Catalase和GPx活性,但是對於肝臟或心臟、腎臟之整體過氧化情形則未見有顯著影響;餵食5%靈芝菌絲體則會降低肝臟脂質過氧化情形,但是對於抗氧化酵素活性及維生素E濃度並沒有顯著影響。 |
英文摘要 | Ganoderma (G) lucidum is a traditional medicine in China and has been used in the promotion of health and longevity for thousands of years. The purpose of this study was to examine whether the antioxidative status of tissues was influenced in mice fed diet containing G. lucidum mycelium. In experiment 1, mice were fed AIN-93G diet containing 0 (C), 1% (G1) and 3% (G3) G. lucidum mycelium for 4 weeks, Ingestion of G. lucidum mycelium did not affect the concentration of thiobarbituric acid-reactive substances (TBARS) in the liver, heart, kidney, and lungs as well as the activity of superoxide dismutase (SOD) in the liver. However, the activities of catalase and glutathione peroxidase (GPx) in the liver were significantly increased in the G3 group of mice. In experiment 2, mice were fed the control diet (C) and diet containing 5% G. lucidum mycelium (G5). The concentration of TBARS in the liver was significantly lower in mice fed G. lucidum mycelium. However, the activities of catalase, GPx, and SOD as well as the α-tocopherol contents in the liver were not affected by G. lucidum mycelium. Taken together, the antioxidant effect of G. lucidum mycelium in mice was contributed by enhancing hepatic enzyme activities of catalase and GPx. In addition, lipid peroxidation in the liver was significantly reduced in mice fed diet containing 5% G. lucidum mycelium. |
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