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| 題 名 | Effect of Glycemic Control on Electrophysiologic Changes of Diabetic Neuropathy in Type2 Diabetic Patients=血糖控制對第二型病糖尿病病人神經病變在神經生理學變化之影響 |
|---|---|
| 作 者 | 黃俊強; 陳天文; 翁銘正; 李佳玲; 曾湘潔; 黃茂雄; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
| 卷 期 | 21:1 民94.01 |
| 頁 次 | 頁15-21 |
| 分類號 | 415.668 |
| 關鍵詞 | 第二型糖尿病; 糖尿病神經病變; 神經傳導速度; Type 2 diabetes; Diabetic neuropathy; Nerve conduction velocity; |
| 語 文 | 英文(English) |
| 中文摘要 | 糖尿病神經病變是糖尿病常見的併發症之一。許多研究已發現在第一型糖尿病人上有效地控制血糖,對於減緩神經傳導速度的變化是有益處的。但很少研究針對第二型糖尿病的糖尿病神經病變。此次研究的目的在探討第二型糖尿病血糖控制與糖尿病神經病變之電氣生理學變化的關係。共收集57位有神經病變的第二型糖尿病病人。腓骨運動神經、脛骨運動神經及腓腸神經之神經傳導測試分別在研究開始時及 24 +/- 3.12 個月後追蹤時量測。個別神經變化以變化百分比 (PC) 表示,而變化百分比是由〔(追蹤時的傳導數值-開始時的傳導數值)/開始的傳導數值 x 100%〕 計算而得。而整體的神經生理變化則以個別變化百分比加成之總和表示。平均 HbA1c 為每三個月測得的 HbA1c 平均而得。研究結果顯示腓骨運動神經、脛骨運動神經及腓腸神經之神經傳導速度變化百分比在平均HbA1c 8.5﹪的病人,而且神經傳導速度的變化百分比總合 (SPCV) 與平均HbA1c呈現顯著負相關。而神經傳導速度的變化百分比總合 (SPCV)在有或無高血壓、高三酸甘油脂血症和低高密度膽固醇的病人間並無顯著差異。結論,高血糖是第二型糖尿病病人的神經生理學變化的重要病因。此外,當平均 HbA1c 高於 8.5 時,將會造成神經生理學上顯著的惡化。 |
| 英文摘要 | Diabetic neuropathy is a common complication of diabetes mellitus. Effective blood glucose control retards changes in nerve conduction velocity in type 1 diabetes. This study examined the relationship between glycemic control and electrophysiologic changes in diabetic neuropathy in 57 type 2 diabetic patients. Nerve conduction in the peroneal motor nerve, tibial motor nerve, and sural nerve were measured at study entry and at follow-up 24 +/- 3.12 months later. Changes in individual nerves are expressed as a percentage change (PC) and overall electrophysiologic changes are expressed as the sum of individual PCs. The PCs for peroneal motor nerve velocity, tibial motor nerve velocity, and sural nerve velocity were all lower in patients with a mean HbA1c of 8.5% or less compared with those in patients with a mean HbA1c of more than 8.5%, and SPCV (sum of PC in velocity) was significantly inversely correlated with mean HbA1c. However, there was no significant difference in SPCV in subjects with or without hypertension, hypertriglyceridemia, or low high-density lipoprotein cholesterol concentration. In conclusion, hyperglycemia is the most important etiology for electrophysiologic progression in type 2 diabetic patients. Furthermore, a mean HbA1c of more than 8.5% will result in significant deterioration in electrophysiology. |
本系統中英文摘要資訊取自各篇刊載內容。