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題名 | 複方「養肝湯1號與2號」對大鼠保肝效果之研究=Hepatoprotective Effects of the Folk Medicines of "Yan-Kan-Tang No.1" and "Yan-Kan-Tang No.2" on Rats |
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作者 | 胡敏夫; 顏銘宏; 廖俊旺; 劉光隆; Hu, Min-fu; Yen, Ming-hong; Liao, Jiuun-wang; Liu, Kun-long; |
期刊 | 作物、環境與生物資訊 |
出版日期 | 20041200 |
卷期 | 1:4 2004.12[民93.12] |
頁次 | 頁229-238 |
分類號 | 434.92 |
語文 | chi |
關鍵詞 | 中草藥; 複方; 保肝效果; 乙醯氨基酚; 水飛薊素; Crude drugs; Prescription; Hepatoprotective effect; Acetaminophen; Silymarin; |
中文摘要 | 摘要 由行政院農業委員會農業試驗所生產 九種臺灣民間常用的保肝草藥,分別以全株 或根為材料組成養肝湯1 號及2 號複方,經 水煎、濃縮及冷凍乾燥所得凍晶粉末產率 22.06 %,以口服300 及500 mg kg-1 二種劑 量, 分別進行對位乙醯氨基酚 acetaminophen (APAP) 500 mg kg-1 劑量 誘發大鼠急性肝炎之保肝效果評估,結果顯 示,經口服養肝湯1 號300 mg kg-1 bw 劑 量後注射APAP,體內出現顯著保肝的效 果,其SGOT 及SGPT 值(U L-1),分別低於 APAP 組與silymarin 保肝藥劑組,差異達 5 % 顯著水準。此情形續經肝切片檢查發 現,口服養肝湯1 號300 mg kg-1 bw 劑量 24 hr 後,經注射APAP 之大鼠肝臟中央區 出血(centrizonal hemorrhagic)、壞死及淋 巴球(lymphocytes) 與kupffer 細胞的聚 集,引起發炎等現象出現明顯抑制。對大鼠 肝急毒性(LD50)評估上,發現對大鼠之口服 急毒性之LD50 值大於10 g kg-1 bw,口服 急毒性等級屬『正常使用時無毒性(unlikely to present hazard in normal use) 』。 |
英文摘要 | ABSTRACT The folk medicines of “Yan-Kan-Tang No.1 (YKT No.1) ” and “Yan-Kan-Tang No.2 (YKT No.2) ” were made of nine different crude drugs collected from Taiwan Agricultural Research Institute Medicinal Garden, Wufeng, Taiwan. The effective portions of these crude drugs were either roots or whole plants. The concentrated powder was made from aqueous extracts of the crude drugs, with the recovery rate of 22.06%, and was used to feed the rats for evaluating its hepatoprotective effect. Two different doses, 300 and 500 mg kg-1 bw, were given separately before the acetaminophen-induced hepatotoxicity occurred at dose of 500 mg kg-1 bw, and then the activities of transaminases of SGOT and SGPT (UL-1) in rats were significantly decreased after the treatment with YKT No.1 at the rat of 300 mg kg1 relative to those of the acetaminophen and silymarin-treat group. The morphological changes in the hepatic tissue were evident. Symptoms appeared from slight to moderate in focal vacuolization of centrilobular hepatocytes, in broad inflammatory infiltration of lymphocytes, and in appearance of kupffer cells around the central vein in the liver of rats treated with acetaminophen. For an oral toxicity study of YKT No.1, it indicated that the acute oral LD50 was greater than 10 g kg-1 bw in rats, suggesting that the oral dose used for this study caused no hazardous effect to mammalians. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。