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題名 | 砷暴露地區居民發炎因子基因多形性與頸動脈粥狀硬化之相關性=The Association between Carotid Atherosclerosis and Inflammatory Gene Polymorphisms among Residents in an Arsenic-endemic Area |
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作者 | 謝宜蓁; 洪啟宗; 王淵宏; 陳建仁; 邱弘毅; | 書刊名 | 臺灣公共衛生雜誌 |
卷期 | 24:1 2005.02[民94.02] |
頁次 | 頁64-72 |
分類號 | 415.384 |
關鍵詞 | 砷; 頸動脈粥狀硬化; 細胞激素; 化學激素; 黏附因子; Arsenic; Carotid atherosclerosis; Cytokine; Chemokine; Adhesion molecule; |
語文 | 中文(Chinese) |
中文摘要 | 目標:探討砷暴露與發炎因子基因多形性對於頸動脈粥狀硬化的獨立及交互作用之關係。方法:由民國86年於蘭陽盆地進行之四十歲以上居民健康檢查且接受過杜卜勒超音波(Duplex ultrasonography)頸動脈超音波檢查的民眾作為研究母群。隨機選取以頸動脈內膜厚度(intima media thickness,IMT)大於1.0或斑塊指數(plaque score)大於1者共332人為病例組,對照組共302人,進行發炎因子包括細胞激素[白血球介素-1接受體拮抗者(interleukin-1 receptor antagonist, IL-1RN)、腫瘤壞死因子(tumor necrosis factor-, TNF-)]、化學激素[單核球化學趨附蛋白-1(monocyte chemoattractant protein-1, MCP-1)]及黏附因子[E-選擇性蛋白(E-selectin)、細胞內黏附分子-1(intercellular adhesion molecule-1, ICAM-1)]等基因多形性的分析。結果:在調整年齡、性別、抽菸、收縮壓以及總膽固醇等傳統危險因子之後,各基因型變異者均會增加罹患動脈粥狀硬化的危險性,但未達統計顯著水準。進一步合併飲水砷濃度小於等於50 g/L時,MCP-1基因型為G/G者,其危險性是基因型A/A者的4倍,達統計顯著意義(p<0.01)。結論:化學激素MCP-1基因多形性在砷暴露環境危害較小的情形下較為明顯,然當環境危害高於某一程度時,基因對於疾病的影響將會被進一步修飾,降低其危險性。 |
英文摘要 | Objectives: To investigate the association between carotid atherosclerosis and genetic polymorphisms of inflammatory genes among residents in the Lanyan Basin which was a newly confirmed arsenic-endemic area. Methods: Residents aged ?0 years were recruited and examined for carotid atherosclerosis by Duplex ultrasonography. A total of 332 subjects were randomly selected from the study population as carotid atherosclerosis patients based on their health examination reports with IMT ?.0 mm and a plaque score ?. Controls were 302 subjects with IMT<1.0 mm and a plaque score<1. Genetic polymorphisms of IL-1RN, TNF-, MCP-1, E-selectin, and ICAM-1 were detected by PCR and RFLP. Results: After adjustment for age, sex, tobacco smoking, systolic blood pressure and total cholesterol, the study subjects whose inflammatory gene with variant genetic type have non-significant increased risk for development of carotid atherosclerosis. For study subjects who drank well-water with an arsenic concentration lower than 50 g/L, those who with MCP-1 G/G genotype have a four-fold risk of carotid atherosclerosis than those who with A/A genotype after adjusting the carotid atherosclerosis related risk factors. However, the risk can not be found for study subjects who drank well-water with an arsenic concentration greater than 50 g/L. Conclusions: The study suggested that the arsenic exposure had more significant influence on carotid atherosclerosis than on human susceptibility. |
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