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題名 | 中藥對狼瘡性腎炎之療效=Herbal Medicine Effects on Lupus Nephritis |
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作者 | 張德明; |
期刊 | 中醫藥年報 |
出版日期 | 19980500 |
卷期 | 16:2 1998.05[民87.05] |
頁次 | 頁85-94 |
分類號 | 413.34 |
語文 | chi |
關鍵詞 | 中藥; 全身性紅斑性狼瘡; 細胞激素; |
中文摘要 | 以免疫抑制劑或大量類固醇治療狼瘡性腎炎已成為模式,但繼 發而來的副作用,卻在臨床上造成極大困擾。 目前已知狼瘡性腎炎的產生與細胞激素關係密切,本實驗採用 該兩種藥物做研究主要題材,並加入白刺杏、白粗糠、水丁香、咸 豐草、紅色見笑根、黑乃爾等常用治療腎臟疾患的中藥一併研究。 本實驗使用狼瘡性腎炎的老鼠模型,即MRL/1pr每周一、三、 五以胃管灌食,同時收集其尿液,血液(眼窩後採血),冰凍存放, 以為進一步分析。 尿蛋白以全自動血液生化分析儀,血清中第一介白質濃度以免 疫酵素分析法測定。同時最後再取出老鼠腎組織及脾臟,以觀察其 病理組織變化,及第一介白質在腎組織上的基因表現。 結果顯示,中藥對尿蛋白及體重皆無影響,但雷公藤可有效抑 制血清中第一介白質濃度,甚至抑制腎臟第一介白質基因表現,但 對脾臟中第一介白質則無影響。在動物實驗中,此為極重要發現。 鑑於已有相當紅班性狼瘡患者使用雷公藤等中藥自我醫療,這 方面的研究將提供患者正確知識,並為中醫藥研究深入基礎,走入 臨床奠下根基。 |
英文摘要 | Nephritis has long been considered one of the most ominous components of systemic lupus erythematosus. The availability of inbred mice that spontaneously develop a disease similar to systemic lupus erythematosus in humans has facilitated numerous studies of the immunopathogenesis and therapy of this clinically important entity. Some traditional Chinese herbal medicines have been reported to be effective in immunoregulation. Thepurpose of this study was to assess the effect of these herbal medicines on the preservation of renal function in mice with lupus glomerulonephritis. MRL-lpr/lpr mice were randomized to receive those medicines which include Pai Tzu Hsing, Pai Tsu Kang, Shui Ting Hsiang, Hsien Feng Tsao, Chien Hsiao ken (red), Hai Nai Erh, Tripterygium Wilfordii Hook f (TWHf), and Tetrandrine in serial diluted concentrations. The clinical, renal, and serologic characteristics of the mice at study entry were recorded, and be followed up every week. In addition to the routine histologic assessment of renal tissue, the cytokine (interleukin-1) gene expression also was determined based on its definite role in the pathogenesis of lupus nephritis. The results demonstrated that TWH could inhibit both serum and tissue IL-1 gene expression. However, all of the tested medicines had no effects on urine protein loss, body weight, This study is the first trial with Chinese herbal medicines to observe their effects on lupus nephritis in animal models, and will provide scientific basis for clinical usiog of herbal medicine in lupus nedhritis. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。