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頁籤選單縮合
題名 | A New Model for in Vitro Corneal Epithelial Wound Healing Study=角膜表皮傷口癒合研究的一個新模式 |
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作者 | 林昌平; Lin, Chang-ping; Boehnke,Matthias; |
期刊 | The Kaohsiung Journal of Medical Sciences |
出版日期 | 19970800 |
卷期 | 13:8 1997.08[民86.08] |
頁次 | 頁475-479 |
分類號 | 416.711 |
語文 | eng |
關鍵詞 | 角膜表皮; 傷口癒合; Corneal epithelium; Photokeratectomy; Wound healing; |
中文摘要 | 本實驗之目的在建立一個無需照相記錄及計算傷口面積之活體外角膜表皮癒合模式。 以準分子雷射在28隻豬眼角膜上切削表皮傷口,包括直徑2.0mm,8眼;1.8mm,8眼;1.5mm,12眼;所有傷口深度皆為70μm。於切削後,將眼球置入培養箱中,於玻璃體中灌注TC-199培養液,每組8眼以TC-199點眼,觀察其表皮癒合之速度。另外1.5mm,4眼則點0.02% Benzalkonium Chloride。接受TC-199點眼之傷口平均癒合時間是:2.0mm組31.75±6.18小時,1.8mm組28.75±3.85小時,1.5mm組24.50±1.77小時。以Benzalkonium Chloride點眼之傷口經36小時仍未癒合。另外12個未經準分子雷射處理之豬眼,以相同條件培養以觀察眼壓之變化,於24小時後其眼壓為15.9至20.6mmHg,平均19mmHg。 本研究顯示於利用小傷口角膜表皮之癒合模式,可以約在24小時測知藥物對於角膜表 皮傷口癒合之影響。 |
英文摘要 | A new model for an epithelial wound healing study in pig eyes has been developed in which the excimer laser was used for ablation to create an epithelial wound with precise depth and size. The purpose of this study was to set up an In vitro epithelial wound healing model without photography and defect area measurement. In the study twenty-eight pig eyes received phototherapeutic keratectomy (PTK) with the following diameters: eight at 2.0mm, eight at 1.8mm, and twelve at 1.5mm. All the wounds were 70μm in depth. Following PTK, the eyeballs were placed in an incubator, and perfused with TC-199 media by vitreous puncture. TC-199 was then used to rinse eight eyeballs from each group. The remaining, four eyes from the 1.5mm group were rinsed with 0.02% Benzalkonium Chloride on an epithelial wound. For the eves rinsed with TC-199 the average healing time for the 2.0mm group was 31.75 ± 6.18 hours; the 1.8mm group was 28.75 ± 3.85 hours, and the 1.5mm group was 24.5 ± 1.77 hours. The corneas rinsed with Benzalkonium Chloride did not heal after 36 hour’s observation. Twelve eyeballs without PTK were perfused under the same criteria to evaluate the change of IOP. Following twenty-four hours the IOP range was 15.9 to 20.6 mmHg with an average of 19.0 mmHg. This study revealed that the healing time decreased as the wound diameter became smaller and the healing was retarded by the drug effect. With this model, the drug influences on corneal epithelial wound healing can be evaluated and the result is revealed in approximately twenty-four hours. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。