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題名 | Expression of LEF1 Is an Independent Prognostic Factor for Patients with Oral Squamous Cell Carcinoma= |
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作者 | Su, Min-cheng; Chen, Chun-ting; Huang, Fang-i; Chen, Yu-ling; Jeng, Yung-ming; Lin, Chiao-ying; |
期刊 | Journal of the Formosan Medical Association |
出版日期 | 20141200 |
卷期 | 113:12 2014.12[民103.12] |
頁次 | 頁934-939 |
分類號 | 416.94 |
語文 | eng |
關鍵詞 | Immunohistochemistry; LEF1; Oral squamous cell carcinoma; Prognosis; |
英文摘要 | Background/Purpose: Lymphoid-enhancing factor 1 (LEF1) is a transcription factor mediating Wnt/b-catenin signaling. In this study, we analyzed the clinicopathologic significance of LEF1 expression in oral squamous cell carcinoma (OSCC). Methods: Expression levels of LEF1 in 135 cases of OSCC were determined by immunohisto-chemistry. The results were correlated with clinicopathologic parameters and patient outcome. Results: LEF1 was only occasionally detected in basal and parabasal cells of nontumorous squamous epithelium. Overexpression of LEF1 was observed in 33 of 135 OSCCs (24%). LEF1 was more frequently expressed in moderately to poorly differentiated cancer (p Z 0.0035) and was associated with lymphovascular invasion (p Z 0.0252). Overexpression of LEF1 was significantly associated with poor prognosis (p Z 0.0176, hazard ratio Z 1.96, 95% CI Z 1.02e3.75). Multivariate analysis revealed LEF1expression and margin status to be the significant independent predictors for overall survival. Conclusion: Our study suggests LEF1 expression in OSCC may play an important role in tumor progression and can be served as a predictor of poor prognosis for patients with OSCC. Copyright ª 2013, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved. |
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