頁籤選單縮合
題名 | Neurobiological Research in Autism=自閉症的神經生物學研究 |
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作者 | 蔡逸周; Tsai, Luke Y.; |
期刊 | 臺灣精神醫學 |
出版日期 | 20030600 |
卷期 | 17:2 2003.06[民92.06] |
頁次 | 頁83-101 |
分類號 | 415.986 |
語文 | eng |
關鍵詞 | 自閉症; 神經生物學研究; 神經病理學; 神經化學; 免疫學; 遺傳學; Autism; Neurobiological research; Neuropathology; Neurochemistry; Immunology; Genetics; |
中文摘要 | 大多數自閉症領域的權威都同意神經生物學因素在自閉症的成因中具有決定性的份量。自閉症的神經生物學研究已經發現各種異常。然而,尚未有任何單一的異常有一致性的發現,而這些發現在病因學探討上的績用更是混沌不明。這些發現的不一致有些是因為方向法學上的侷限造成,但也顯示了自閉症是包括了好幾個不同亞群的異質性神經發展障礙。期待未來的研究可以找出自閉症障礙各亞群的生物學病因範圍。未來自閉症的研究績該繼續病重進一步的次分類。這主的研究取向可以使研究者選取更同質性的個案群來進行未來的神經生物學研究。如此一來,各別獨立的研究團隊將可期待得到更一致的研究成果,進一步澄清各種因素在形成自閉症中所扮演的的色。未來的研究方向也績該強調神經生物學有關學門的跨領域合作與整合。隨著進一步瞭解自閉症的神經生物學機制,將得以開發更有效的神經生物治療,包括藥物及非藥物。另一方面,隨著更瞭解導致自閉症的異常基因,我們將更能知道如何預防自閉症發生並且實際執行。 |
英文摘要 | Most authorities in the field of autism agree that neurobiological factors are of crucial importance in terms of cause(s) of autism. Neurobiological investigations in autism have found various abnormalities. However, no single measure of the abnormalities has been found consistently, and the etiological implications of these findings are far from clear. While some of the inconsistencies are due to methodological shortcomings, they also reflect that autism is a heterogeneous neurodevelopmental disorder that includes several distinct subtypes. It is anticipated that future studies will determine a range of biological etiologies for the subgroups constituting autistic disorder. Future research in autism should continue to emphasize the further subclassification of autism. Such an approach will enable investigators to select more homogeneous groups of individuals for future neurobiological research. From this approach, more consistent results could be expected from various independent research groups to further clarify the role of the various factors which contribute to autism. Future research direction should also emphasize the collaboration and integration across a range of neurobiological disciplines. With the advanced understanding of the neurobiological mechanisms of autism, more effective neurobiological treatments, including both medication and nonmedication interventions, can be developed. On the other hand, with better understanding of the mutant genes responsible for autism, we can expect significant advances in the learning and practicing of how to prevent the development of autism. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。