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題名 | Hearing Loss in Patients with Nasopharyngeal Carcinoma after Chemotherapy and Radiation=放射線治療後鼻咽癌患者之聽力變化研究 |
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作者 | 王凌峰; 郭文烈; 何坤瑤; 李家和; 林至欣; Wang, Ling-feng; Kuo, Wen-rei; Ho, Kuen-yao; Lee, Ka-wo; Lin, Chih-shin; |
期刊 | The Kaohsiung Journal of Medical Sciences |
出版日期 | 20030400 |
卷期 | 19:4 2003.04[民92.04] |
頁次 | 頁163-169 |
分類號 | 416.879 |
語文 | eng |
關鍵詞 | 放射線治療; 鼻咽癌; 聽力喪失; Nasopharyngeal carcinoma; Radiotherapy; Radiation injury; Hearing loss; |
中文摘要 | 有鑑於放射線治療可能對聽力造成不良的影響,本文針對鼻咽癌患者接受放射線治療之聽力變化,作一長期追蹤研究。於放射線治療前及治療後之固定時間,均給予研究對象詳細的聽力檢查。並詳細分析患者年齡、有無接受化學治療、放射線治療前的聽力及放射線治療後有無出現中耳積水、是否會影響放射線治療後之聽力變化。共 150 位患者、261 隻耳朵進行分析,平均追蹤時間 36 個月,最長追蹤時間為 10 年。在追蹤期間共有 8.9-28.8% 患者之骨傳導於語言頻率區(500、1,000、2,000 赫茲之聽力的平均值)至少有 10 分貝之聽力喪失,而於高頻區(4,000 赫茲)則有 18-34.2% 患者至少有 10 分貝之聽力喪失。研究分析後發現患者之年齡和語言頻率區聽力變化有關,且放射線治療後出現中耳積水,會顯著影響語言頻率區及高頻區的聽力變化。至於患者放射線治療前的聽力狀況及有無接受化學治療,則對患者之聽力變化無顯著影響。放射線治療後很快就會出現聽力喪失的情況,早期的變化有些是可逆的,但是放射線對於聽力的影響則是慢性且持續存在的。 |
英文摘要 | In light of the possible adverse effects of radiation on hearing, we conducted a study to evaluate the long-term sensorineural hearing status following radiotherapy (RT) in patients suffering from nasopharyngeal carcinoma. Audiologic examinations were performed at regular intervals before and after RT. We also analyzed the effects of age, chemotherapy, pre-RT hearing status, and post-RT otitis media with effusion (OME) on post-RT hearing change. A total of 150 patients (261 ears) were enrolled in this study and followed up for a mean of 43.8 months. After RT, 8.9-28.8% of ears had at least a 10 dB loss in bone conduction threshold at speech frequency, which was defined as an average of hearing threshold at 0.5 kHz, 1 kHz, and 2 kHz, while the percentage was 18-34.2% at 4 kHz. Patient age was related to these changes at speech frequency, and the presence of post-RT OME was related to significant loss at both speech frequency and 4 kHz. Pre-RT hearing status and chemotherapy did not influence hearing change. To sum up, sensorineural hearing loss began as early as after completion of RT. Early changes may be transient, but the effect of radiation on hearing tended to be chronic and progressive. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。