頁籤選單縮合
題名 | Cytotoxic Constituents from the Fruit of "Diospyros Ferrea"= |
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作者 | 郭曜豪; 黎世源; 沈建昌; 楊禮明; 黃慧琪; 廖文斌; 張誌益; 郭悅雄; 陳介甫; Kuo, Yao-haur; Li, Shyh-yuan; Shen, Chien-chang; Yang, Li-ming; Huang, Hui-chi; Liao, Wen-bin; Chang, Chi-i; Kuo, Yueh-hsiung; Chen, Chieh-fu; |
期刊 | 中華藥學雜誌 |
出版日期 | 19970800 |
卷期 | 49:4 1997.08[民86.08] |
頁次 | 頁207-216 |
分類號 | 414.51 |
語文 | eng |
關鍵詞 | Diospyros ferrea; Ebenaceae; Naphthoquinones; Triterpenes; Sterols; |
英文摘要 | Two naphthoquinones, isodiospyrin (1) and 8'-hydroxyisodiospyrin (2) six triterpenes, friedelin (3) epifriedelinol (4) lupeol (5) lupenone (6) betulin (7) and lup-20(29)-en-3 β,30-diol (8) and two sterols, β-sitosterol (9a) and stigmasterol (9b), were isolated from the n-hexane extract of the fruit of Diospyros ferrea. All of these compounds were evaluated for in vitro cytotoxicity in 4 cancer cell lines. Compounds 1 and 2 exhibited strong cytotoxicity against Hep-3B, KB, COLO-205 and HeLa cells (ED�t =0.17,1.72,0.16 and 0.21 μ g/mL for 1; ED�t = 1.31,1.75,1.96 and 1.79 μ g/mL for 2). |
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