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題名 | The Analgesic Effect of PCA Buprenorphine in Taiwan's Gynecologic Patients=在臺灣地區之婦科病人經靜脈病人自控止痛系統給予Buprenorphine緩解手術後疼痛之研究 |
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作者 | 何善台; 王志中; 劉杭生; 曾劍英; 廖文進; Ho, Shung-tai; Wang, Jhi-joung; Liu, Hang-seng; Tzeng, Jann-inn; Liaw, Wen-jinn; |
期刊 | 麻醉學雜誌 |
出版日期 | 19971200 |
卷期 | 35:4 1997.12[民86.12] |
頁次 | 頁195-199 |
分類號 | 417.372 |
語文 | eng |
關鍵詞 | 麻醉止痛劑:Buprenorphine; 嗎啡; 疼痛:手術後; Narcotics:Buprenorphine; Morphine; Pain:Postoperative; |
中文摘要 | 背景:對於嚴重手術後疼痛,適切的疼痛緩解是絕對必須的。在國外的研究報告中 指出對於此類疼痛,buprenorphine可以達到一個很好的止痛作用。在本研究中我們評估在 臺灣地區婦科病人使用靜脈注射buprenorphine之止痛療效,並以傳統止痛劑嗎啡為對照組 來比較二種藥物之止痛強度。 方法:50位接受經腹腔子官切除手術之病人,於手術前依隨機分為二組(每組25人)。在 脊髓麻醉及手術後,第一組病人接受以病人自控止痛糸統經靜脈注射buprenorphine以治療 手術後疼痛。而在第二組之病人接受以病人自控止痛糸統經靜脈注射嗎啡治療手術後疼痛。 於48小時內之止痛藥的需求次數及消耗量、生命徵象(如心跳、血壓、呼吸次數)及副作用(如 噁心、嘔吐及皮膚癢症)都被記錄並統計。 結果:本研究結果顯示,不論何種治療方式,病患在手術後第一天及第二天的疼痛分數皆 很類似,二種治療方式皆可達到有效的止痛效果。兩組對於止痛藥的需求次數相似,在二天 內第一組buprenorphine的消耗量為1.5±0.6毫克,第二組嗎啡的消耗量為36±7毫克,而 在止痛強度的比較下,buprenorphine比嗎啡強24倍。在副作用方面,二組皆僅呈現輕微的 副作用。 結論:我們認為在臺灣之婦科病人,使用靜脈注射buprenorphine可以有效的緩解手術後 疼痛,而其止痛效果比嗎啡強24倍。 |
英文摘要 | Background: The aim of this study was to evaluate the analgesic effect of PCA buprenorphine (intravenous) on postoperative pain in gynecologic patients of Taiwan and the potency ratio of buprenorphine versus morphine, a commonly used potent analgesic. Methods: Fifty women undergoing abdominal total hysterectomy under spinal anesthesia were enrolled into the investigation. Patients were randomly divided into 2 groups (n = 25 each). Group 1 received intravenous buprenorphine using PCA device for the management of postoperative pain, whereas Group 2 received PCA morphine for the same purpose. During the first 48 hours postoperatively, we collected the following data: demand and delivery of analgesics, pain scores, vital signs, nausea, vomiting and pruritus. Results: Despite different treatments, we found that pain scores on day 1 and day 2 postoperatively were low and were not significantly different between groups. Also, times of demand for delivery of PCA medication were not significantly different between groups. The cumulative consumption of buprenorphine and morphine within 48 h were 1.5 ± 0.6 mg and 36 ± 7 mg, respectively. The potency ratio between buprenorphine and morphine was 24:1. Both treatments showed only minor side effects. Conclusions: We found that PCA buprenorphine (intravenous) could be effective in the treatment of postoperative pain in the gynecologic patients in Taiwan and the potency ratio of buprenorphine versus morphine appeared to be 24:1. |
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