頁籤選單縮合
題名 | (3'S,4'R)-N-(6-Cyano-3,4-dihydro-2,2-dimethyl-3-hydroxy-2H-1-benzopyran-4-yl)-2-hydroxy-2-trifluoromethylpropamides as Potassium Channel Openers= |
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作者 | 邱欣怡; 程正禹; Chiu, Hsin-i; Cheng, Chen-yu; |
期刊 | 中華藥學雜誌 |
出版日期 | 19990200 |
卷期 | 51:1 1999.02[民88.02] |
頁次 | 頁87-92 |
分類號 | 418.1 |
語文 | eng |
關鍵詞 | Potassium channel openers; Cromakalim; ZD6169; Bladder-se-lective; |
英文摘要 | Based on a combination of the structural features of lemakalim and ZD6169, (2S,3'S,4'R)-N-(6-cyano-3,4-dihydro-2,2-dimethyl-3-hydroxy-2H-1-benzopyran-4-yl)-2-hydroxy-2-trifluoromethylpropamides ((-)-6) and its C-2 epimer (+)-7 were synthesized from (3S,4R)-6-cyano-3,4-epoxy-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran((-)-3). Compound 6, which has the same configuration (S) at C-2 as that of ZD6169, showed significant potassium channel activation activity on rat portal vein and rat bladder detrusor strips (EC□=2.5 and 5.4 μM respectively); while its epimer 7 was only weakly active. |
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