查詢結果分析
來源資料
相關文獻
- 抗菌劑在養殖魚類的藥物動力學研究(1)--在不同給藥方式下點帶石斑Epinephelus coioides對Flumequine之吸收、分布與排除
- Pharmacokinetics of Oxolinic Acid in Orange-spotted Grouper, Epinephelus coioides, after Single Oral Administration at 24℃
- A Dose-Dependent Pharmacokinetic Study of Levodopa by Intramuscular Administration in Rabbits
- 選擇性血清素再吸收抑制劑
- Fluvoxamine對Clozapine藥物動力學之影響
- 藥物動力學在臨床上之應用:藥物動力學服務
- 碳酸酐酶抑制劑6-Hydroxyethoxy-2-benzothiazole Sulfonamide靜脈注射後之兔眼藥物動力學
- 碳酸酐酶抑制劑6-Hydroxyethoxyzolamide局部點眼後之兔眼藥物動力學
- 新抗癲癇藥
- Pharmacokinetics and Brain Regional Distribution of caffeine in Rats
頁籤選單縮合
題名 | 抗菌劑在養殖魚類的藥物動力學研究(1)--在不同給藥方式下點帶石斑Epinephelus coioides對Flumequine之吸收、分布與排除=Pharmacokinetics of Antibacterial Agents in Cultured Fish(Ⅰ)--Absorption, Distribution and Elimination of Flumequine in Orange-Spotted Grouper Epinephelus Coioides after Various Routes of Administration |
---|---|
作者 | 郭錦朱; 廖一久; Guo, Jiin-ju; Liao, I Chiu; |
期刊 | 水產研究 |
出版日期 | 19961200 |
卷期 | 4:2 1996.12[民85.12] |
頁次 | 頁117-126 |
分類號 | 439.6 |
語文 | chi |
關鍵詞 | 點帶石斑; 藥物動力學; 生物可用率; Flumequine; Grouper epinephelus coioides; Pharmacokinetics; Bioavailability; |
中文摘要 | 本文旨在探討靜脈注射、連續口投與藥浴等不同給藥方式下,點帶石 斑Epinephelus coioides 對 Flumequine 的吸收、分布與排除之狀況,目的在建 立藥物動力學參數與其生物可用率資料。實驗結果顯示,以 20 mg/kg魚體重劑 量之藥物對點帶石斑靜脈注射投藥,其血液之曲線下面積 (AUC)為 249 ?慊? 沼/ml,血中最高藥物濃度 (Cmax) 達 42.3 ?慊/ml ,分布半生期 (t1/2 ) 為 0.3 h,排除半生期 (t1/2 ) 為 10.5 h。另以 20 mg/kg 魚體重/天之劑量對點帶石斑 連續口投給藥四天,結果魚體對藥物的吸收,在第二天時達穩定狀態,其平均 血中濃度 (Css ave) 為 4.6 ?慊/ml。以劑量 20 ppm 對點帶石斑連續藥浴三天, 結果魚體內藥物濃度,在連續藥浴三天後達最高,其 Tmax 為三天,Cmax 為 1.2?慊/ml。至於將藥物經口投與藥浴方式投藥之生物可用率,分別為 44 和 9%。 |
英文摘要 | The absorption, distribution and elimination of flumequine in orange- spotted grouper Epinephelus coioides were studied after various routes of administration at 23oC. The area under the serum concentration-time curve (AUC) was 249 ?慊?? h/ml after the fish was given a single intravenous injection at a dose of 20 mg/kg b.w. Distribution and elimination half-life (t1/2?? t1/2?? of flumequine was 0.3 and 10.5 h, respectively. The drug was absorbed and eliminated rapidly. Flumequine reached a peak concentration (Cmax) of 42.3 ?慊/ml in serum. A steady-state level of flumequine was achieved on the 2nd day in serum, muscle, liver and kidney of fish after four consecutive days of oral administration at dose of 20 mg/kg b.w./day, and an average concentration (Css) of flumequine in serum was 4.6 ?慊/ml. The peak of flumequine concentration in serum was 1.2 ?? g/ml on the 3rd day after consecutive bathing administration at dose of 20 ppm for three days. The bioavailability of oral and bathing administration was 44 and 9%, respectively. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。