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題名 | Risk Factors Leading to Ceftriaxone-Associated Biliary Pseudolithiasis in Children=引起Ceftriaxone導致兒童膽假性結石的危險因子 |
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作者 | 江文山; 陳清裕; Kong, Man-shan; Chen, Ching-yuh; |
期刊 | 長庚醫學 |
出版日期 | 19960300 |
卷期 | 19:1 1996.03[民85.03] |
頁次 | 頁50-54 |
分類號 | 417.6246 |
語文 | eng |
關鍵詞 | 膽假性結石; Ceftriaxone; Gallbladder pseudolithiasis; |
中文摘要 | Ceftriaxone為一強力的第三代頭孢子菌抗生素,對多種常見的兒童感染有很好的療效,它的副作用可能會造成膽囊暫時性結石或稱為膽假性結石,本研究自1992年7月至1994年6月共收集151位兒科病童使用Ceftriaxone治療腸炎病人,所有病童都接受此抗生素每天最少50mg/kg治療3天以上,並以腹部超音波對病人膽囊作前膽性的追?,發現有5位病童發生膽假性結石,禁食與病童年齡大於24個月可能為導伢此現像的危險因子(p<0.05),雖然病人使用此抗生素每天超過50mg/kg並治療5天以上有較高產生膽假性結石的傾向,但結石產生與否與病人的緎別,使用劑量及治療時間長短無統計上的意義。 |
英文摘要 | Between July, 1992 and June, 1994, 151 pediatric patients who had ceftriaxone therapy for probable or definite bacterial enteritis were prospectively evaluated by serial abdominal ultrasonograpy. All patients received a dose of≧50 mg/kg/day and for a duration of 3 or more days. Five patients developed gallbladder precipitates or pseudolithiasis during treatment. Fasting and patients older than 24 months were probably the significant risk factors associated with this phenomenon (p<0.05). However, no significant differences in sex, does (50 vs. >50 mg/kg/day) or duration of therapy (<5 vs. 5 day) were observed between patients who received ceftriaxone with and with-out the development of this gallbladder abnormality. |
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