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題名 | Spindle Cell Carcinoma of the Lung: A Clinicopathologic Presentation of Three Cases=肺梭狀細胞癌:三病例報告 |
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作者 | 朱國安; 林秀玲; 王鴻昌; 盧朝勇; 蘇建銘; 姜洪霆; Chu, Kuo-an; Lin, Shong-ling; Wang, Hong-chung; Lu, Jau-yeong; Su, Jang-ming; Chiang, Hung-ting; |
期刊 | 中華醫學雜誌 |
出版日期 | 19980300 |
卷期 | 61:3 民87.03 |
頁次 | 頁164-169 |
分類號 | 415.468 |
語文 | eng |
關鍵詞 | 肺腫瘤; 鮮狀上皮細胞癌; 梭狀細胞癌; 免疫組織染色簡題; 肺梭狀細胞癌; Immunohistochemistry; Lung neoplasms; Spindle cell carcinoma; Squamous cell carcinoma; |
中文摘要 | 肺梭狀細胞癌(spindle cell carcinoma)為一少見的原發性肺部腫瘤,其特別性為同時存在上皮癌及類肉瘤成份。我們報導三例罹患下呼吸道梭狀細胞癌的病人,其中兩例為單相腫瘤(monophasic tumor)表現,一例呈雙相腫瘤(biphasic tumor)表現。在光學顯微鏡下,腫瘤的梭狀細胞部分呈現類似肉瘤特徵;若使用抗細胞角質素抗體(anti-cytokeratin antibody)做免疫組織學染色,可發現:不論是單相或雙相腫瘤型態的類肉瘤部分,皆有上皮細胞特徵。目前認為此梭狀細胞可能源自上皮細胞而呈不同程度之間質表現(mesenchymaltransformation)。本文回顧過去文獻曾報導的數個病例,並整理其臨床及病理特徵於後。 |
英文摘要 | Three patients with spindle cell carcinoma located in the lower respiratory tract are presented, including cases of two monophasic and one biphasic tumor. On light microscopic examination, the spindle cell components of the tumors were histologically characterized by sheets of fusiform spindle cells that closely resembled a sarcoma. Keratin expression in the spindle cell components of these tumors, as shown by anti-cytokeratin antibody staining, demonstrated their epithelial nature. It is supposed that the spindle cell component displays a spectrum of phenotypes originating from epithelial cells with varying degrees of mesenchymal transformation. It is difficult to establish a diagnosis of this rare primary pulmonary malignancy prior to surgical intervention. A review of the literature allowed for a summary of the clinicopathologic characteristics of this tumor. |
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