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題名 | 皮膚原藻病--病例報告及文獻回顧=Cutaneous Protothecosis--Report of 5 Cases and Review of the Literature |
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作者 | 洪嘉惠; 郭宏文; 鄭裕文; 邱耀堃; 何宜承; Hung, Chia-hui; Kuo, Hung-wen; Cheng, Yu-wen; Chiu, Yao-kun; Ho, Ji-chen; |
期刊 | 中華皮膚科醫學雜誌 |
出版日期 | 20020900 |
卷期 | 20:3 2002.09[民91.09] |
頁次 | 頁192-199 |
分類號 | 415.725 |
語文 | chi |
關鍵詞 | 皮膚原藻病; Protothecosis; Prototheca; Morula; Iatrogenic cushing syndrome; |
中文摘要 | 皮膚原藻病是一種不常見的疾病,是由無葉綠素的,似海藻單孢子生物,稱為原膜球藻屬所引起。最早是在1894年由Krüger首先提出,自1964年到目前為止不到八十個病例被報告過。此病最常發生在免疫不全的人身上,但是在健康的人也可能見到無症狀自限性的皮膚病灶。吾人提出五個原藻病的病例報告,病理下可見具特徵性的桑椹胚,他們的年齡從48歲到74歲不等,三位女性、兩位男性。五位病例皆是庫欣氏症候群患者,四位有糖尿病,三位病人家中使用地下水,三位在病灶處曾受過傷。臨床表現以出現於四肢浸潤性病灶有多處表淺性潰瘍最為常見。五位病例以抗黴菌藥物治療,效果普遍不佳,三位失去追蹤,其中一例因併發敗血症而死亡。值得一提的是,其中有三位同時罹患疥瘡,而此相關性到目前為止並未被報告過。 |
英文摘要 | Cutaneous protothecosis is an uncommon infection caused by achlorophytic, algae-like unicellular organisms of the genus Prototheca. It was first described by Krüger in 1894 and less than 80 cases have been reported since 1964. It occurs mainly in the immunocompromised patients, otherwise asymptomatic and self-limited cutaneous lesions may be seen in healthy patients. Herein, we present five protothecosis cases with histologically characteristic morula. They aged from 48 to 74 years (3 females, 2 males). All of the five cases had iatrogenic Cushing syndrome, four had diabetes mellitus, three used groundwater in daily life, and three had trauma history. Infiltrative plaques with multiple small ulcers on the extremities are common manifestations. Five cases were treated with antifungal medications, but responses were unsatisfactory and three of the patients lost follow up. One case died of sepsis. Further more, we found that three of them also had scabies at the same time, and this association has not been previously reported. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。